A5068799163- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Spaceflight effects on biology
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
University of Glasgow
2018
Disseminated breast cancer cells have the capacity to metastasise bone marrow and reside in a dormant state within mesenchymal stem cell niche. Research has focussed on paracrine signalling factors, such as soluble proteins, microenvironment. However, it is now clear extracellular vesicles secreted by resident into this microenvironment also play key role initiation of dormancy. Dormancy encourages reduced proliferation migration, while upregulating adhesion, thus retaining Here, MCF7 were...
Mesenchymal stem cells (MSCs) reside quiescently within a specialised ‘niche’ environment in the bone marrow. However, following appropriate signalling cues, MSCs mobilise and migrate out from niche, typically toward either sites of injury (a regenerative response) or primary tumours (an intrinsic homing response, which promotes as cellular vectors for therapeutic delivery). To date, very little is known about MSC mobilisation. By adopting 3D niche model, whereby spheroids are cultured type...