A5006636501- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neural dynamics and brain function
University of Colorado Anschutz Medical Campus
2020-2023
University of Colorado Denver
2017
Abstract Proteins critical for synaptic transmission are non-uniformly distributed and assembled into regions of high density called subsynaptic densities (SSDs) that transsynaptically align in nanocolumns. Neurexin-1 neurexin-3 essential presynaptic adhesion molecules non-redundantly control NMDAR- AMPAR-mediated transmission, respectively, via transsynaptic interactions with distinct postsynaptic ligands. Despite their functional relevance, fundamental questions regarding the nanoscale...
Fear extinction-based exposure therapy is the most common behavioral for anxiety and trauma-related disorders, but fear extinction memories are labile tends to return even after successful extinction. The relapse of contributes poor long-term efficacy therapy. A single session voluntary exercise can enhance acquisition consolidation in male rats, effects on not well understood. Here, we characterized 2 h during phase contextual or auditory learning memory renewal adult, female, Long-Evans...
Vulnerabilities to fear-related disorders can be enhanced following early life adversity. This study sought determine whether post-weaning social isolation (PSI), an animal model of adversity, alters the development fear in innovative conditioned fear. Male and female Sprague-Dawley rats underwent either rearing (SR) or PSI for 4 weeks weaning. Rats were then assigned groups consisting Footshock only, Social stimulus (CS) Paired footshock with a CS. behavior was assessed next day. We...