A5023917462- interferon and immune responses
- Legionella and Acanthamoeba research
- Vibrio bacteria research studies
- HIV Research and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Escherichia coli research studies
- Intimate Partner and Family Violence
- Clostridium difficile and Clostridium perfringens research
- Bacterial Genetics and Biotechnology
- Child Abuse and Trauma
Centre International de Recherche en Infectiologie
2021-2024
Inserm
2021-2024
Université Claude Bernard Lyon 1
2021-2024
École Normale Supérieure de Lyon
2021-2024
Centre National de la Recherche Scientifique
2023-2024
Host actin cytoskeleton is often targeted by pathogenic bacteria through the secretion of effectors. Legionella pneumophila virulence relies on injection largest known arsenal bacterial proteins, over 300 Dot/Icm type 4 system effectors, into host cytosol. Here, we define functional interactions between VipA and LegK2, two effectors with antagonistic activities towards polymerization that have been proposed to interfere endosomal pathway. We confirmed prominent role LegK2 effector in...
Sterile alpha motif domain-containing proteins 9 and 9-like (SAMD9/9L) are associated with life-threatening genetic diseases in humans restriction factors of poxviruses. Yet, their cellular function the extent antiviral role poorly known. Here, we found that interferon-stimulated human SAMD9L restricts HIV-1 late phases replication, at posttranscriptional prematuration steps, impacting viral translation and, possibly, endosomal trafficking. Surprisingly, paralog SAMD9 exerted an opposite...
ABSTRACT Host actin cytoskeleton is often targeted by pathogenic bacteria through the secretion of effectors. Legionella pneumophila virulence relies on injection largest known arsenal bacterial proteins, over 300 Dot/Icm Type 4 Secretion System effectors, into host cytosol. Here we define functional interactions between VipA and LegK2, two effectors with antagonistic activities towards polymerization that have been proposed to interfere endosomal pathway. We confirmed prominent role LegK2...
Abstract Sterile alpha motif domain-containing proteins 9 and 9L (SAMD9/9L) are associated with life-threatening genetic diseases restriction factors of poxviruses. Yet, their cellular function the extent antiviral role poorly known. Here, we found that interferon-stimulated SAMD9L, not SAMD9, restricts HIV-1 replication at translation step, a strong inhibition Transmitted/Founder patient strains. More broadly, SAMD9L primate lentiviruses, but another retrovirus (MLV) or two ssRNA viruses...