A5090474496- NF-κB Signaling Pathways
- interferon and immune responses
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
H. L. Snyder Medical Foundation
2018
Johns Hopkins Medicine
2011-2018
Johns Hopkins University
2011-2018
Structural plasticity of dendritic spines and synapses is a fundamental mechanism governing neuronal circuits may form an enduring basis for information storage in the brain. We find that p65 subunit nuclear factor-κB (NF-κB) transcription factor, which required learning memory, controls excitatory synapse spine formation morphology murine hippocampal neurons. Endogenous NF-κB activity elevated by transmission during periods rapid development. During vitro synaptogenesis, enhances density...
Long-term forms of brain plasticity share a requirement for changes in gene expression induced by neuronal activity. Mechanisms that determine how the distinct and overlapping functions multiple activity-responsive transcription factors, including nuclear factor κB (NF-κB), give rise to stimulus-appropriate responses remain unclear. We report p65/RelA subunit NF-κB confers subcellular enrichment at dendritic spines engineer p65 mutant lacks spine (p65ΔSE) but retains inherent transcriptional...
ABSTRACT Long-term forms of brain plasticity share a requirement for changes in gene expression induced by neuronal activity. Mechanisms that determine how the distinct and overlapping functions multiple activity-responsive transcription factors, including nuclear factor kappa B (NF-κB), give rise to stimulus-appropriate responses remain unclear. We report p65/RelA subunit NF-κB confers subcellular enrichment at dendritic spines engineer p65 mutant lacks spine-enrichment (ΔSEp65) but retains...