A5004274781- Alzheimer's disease research and treatments
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Fluoride Effects and Removal
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Folate and B Vitamins Research
- GDF15 and Related Biomarkers
- Nutritional Studies and Diet
- Biochemical effects in animals
The University of Tokyo
2019-2023
Based on epidemiological and experimental studies, type 2 diabetes mellitus (T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has been recognized as a significant risk factor for Alzheimer's disease (AD). Studies in humans diabetic AD model mice have indicated correlation between increased amyloid deposition brain. Paradoxically, with targeted disruption genes involved signaling pathway showed protective effects against AD-related pathology. These conflicting...
Insulin signaling has been implicated in the metabolism as well aging and longevity. Type 2 diabetes mellitus its core pathology, insulin resistance, also development of Alzheimer's disease (AD) amyloid-β deposition humans. By contrast, genetic ablation insulin/IGF-1 (IIS) pathway components, e.g. receptor substrate (IRS)-2, documented to suppress accumulation brains transgenic mice overexpressing AD mutant β-amyloid precursor protein (APP). Therefore, brain IIS may be a key modifiable...
The insulin/IGF-1 signaling (IIS) regulates a wide range of biological processes, including aging and lifespan, has also been implicated in the pathogenesis Alzheimer's disease (AD). We others have reported that reduced by genetic ablation molecules involved IIS (e.g., insulin receptor substrate 2 [IRS-2]) markedly mitigates amyloid plaque formation brains mouse models AD, although molecular underpinnings amelioration remain unsolved. Here, we revealed, transcriptomic analysis male murine...
糖尿病，高血圧ならびに肥満等の生活習慣病は，特に中年期において認知症の危険因子となることが知られる．生活習慣病は，脳血管障害を介して認知症の病態を促進するほか，Alzheimer病では，インスリン抵抗性等の要因も複合的に病態に関連すると考えられる．生活習慣病に関連する個々の危険因子への介入研究では，認知症に対する予防的効果のエビデンスは不十分であるが，多角的な介入が有効である可能性が示唆されている．
As the result of individual research for nourishing food taken by 87 pregnant women in Tokushima prefecture, we get following data.In former period pregnancy summer, living mountain and fishing village take little V. A C. In farm, mountain, protein. all areas inclusive city Ca.In latter winter, protein, Fe, A,