A5055831788- Protein Degradation and Inhibitors
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ubiquitin and proteasome pathways
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Multiple Myeloma Research and Treatments
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
- Peptidase Inhibition and Analysis
- Sleep and Wakefulness Research
- Hematopoietic Stem Cell Transplantation
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Renal Transplantation Outcomes and Treatments
- Enzyme Catalysis and Immobilization
- Amyotrophic Lateral Sclerosis Research
- Nuclear Receptors and Signaling
- Analytical Chemistry and Chromatography
- Click Chemistry and Applications
- Cervical and Thoracic Myelopathy
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Sarcoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
St. Jude Children's Research Hospital
2011-2024
Fujian Normal University
2012-2013
Harbin Institute of Technology
2012
University of North Dakota
2005-2011
Kosair Children's Hospital
2004
University of Louisville
2004
Baxter (United States)
2004
Research reports on de novo neurogenesis, particularly dopaminergic (DA) neurogenesis in the adult mammalian substantia nigra (SN), remain very controversial. For this reason, we used nestin second intron enhancer-controlled LacZ reporter transgenic mouse model coupled with 1-methyl-4-phyenyl-1,2,3,6-tetrahydropyridine (MPTP) lesion system to investigate whether there are and DA SN of normal Parkinson's disease (PD)-like mice. First, demonstrated presence neural progenitor cells (NPCs),...
Abstract The organization, distribution, and function of neural progenitor cells (NPCs) in the adult spinal cord during motor neuron degeneration amyotrophic lateral sclerosis (ALS) remain largely unknown. Using nestin promoter–controlled LacZ reporter transgenic mice mutant G93A-SOD1 mimicking ALS, we showed that there was an increase NPC proliferation, migration, neurogenesis lumbar region response to degeneration. proliferation NPCs detected by bromodeoxyurindine incorporation staining...
Abstract Adult neural progenitor cells (NPCs) are an attractive source for functional replacement in neurodegenerative diseases and traumatic injury to the central nervous system (CNS). It has been shown that transplantation of stem or NPCs into lesioned region partially restores CNS function. However, capacity endogenous neuronal cell loss recovery spinal cord (SCI) is apparently poor. Furthermore, temporal spatial response adult SCI remains largely undefined. To this end, we have analyzed...
Streptococcus pneumoniae infection is a leading cause of bacterial pneumonia, sepsis and meningitis associated with high morbidity mortality. Type I interferon (IFN-I), whose contribution to antiviral intracellular immunity well established, also elicited during pneumococcal infection, yet its functional significance not defined. Here, we show that IFN-I plays an important role in the host defense against pneumococci by counteracting transmigration bacteria from lung blood. Mice lack type...
Inhibition of members the bromodomain and extraterminal (BET) family proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 BD2) that are necessary recognition acetylated lysine residues in N-terminal regions histones. Chemical matter targets (BETi) also interact via these domains. Molecular cellular data indicate BD2 have different biological roles depending upon their context, with particularly associated cancer. We...
B-cell CLL/lymphoma 10 (BCL10) is crucial for the activation of NF-κB in numerous immune receptor signaling pathways, including T-cell (TCR) and pathways. However, molecular mechanisms that lead to signal transduction from BCL10 downstream effector kinases, such as TAK1 components IKK complex, are not entirely understood. Here we used a proteomic approach identified E3 ligase MIB2 novel component activated complex. In vitro translation pulldown assays suggest direct interaction between MIB2....
Carboxylesterases (CEs) are ubiquitous enzymes that responsible for the metabolism of xenobiotics, including drugs such as irinotecan and oseltamivir. Inhibition CEs significantly modulates efficacy agents. We report here β-lapachone is a potent, reversible CE inhibitor with Ki values in nanomolar range. A series amino phenoxy analogues have been synthesized, although former very poor inhibitors, latter compounds highly effective modulating activity. Our data demonstrate tautomerism...
Immune cell-mediated tissue injury is a common feature of different inflammatory diseases, yet the pathogenetic mechanisms and cell types involved vary significantly. Hypereosinophilic syndrome (HES) represents group diseases that characterized by increased numbers pathogenic eosinophilic granulocytes in peripheral blood diverse organs. On basis clinical laboratory findings, various forms HES have been defined, molecular mechanism potential signaling pathways drive eosinophil expansion...
Regenerative medicine through neural stem cells (NSCs) or progenitor (NPCs) has been proposed as an alterative avenue for restoring neurological dysfunction in amyotrophic lateral sclerosis (ALS). It is critical to understand the organization and distribution of endogenous adult NPCs response motor neuron degeneration before regenerative can be applied ALS therapy. For this reason, we analyzed temporal spinal cord brain using nestin enhancer-driven LacZ reporter transgenic mice (pNes-Tg...
Abstract Pediatric and adolescent young adult (AYA) patients who receive many blood product transfusions, such as individuals with sickle cell disease (SCD), severe aplastic anemia (SAA) or indolent hematologic malignancies, are at high risk for developing donor‐specific antibodies (DSA). DSAs mean fluorescence intensity (MFI) greater than 5000 have been associated significant graft failure, but lower MFI values between 2000 may result in poor function after hematopoietic transplant (HCT)....
A fetus with features of hydrops was given intra-uterine transfusion at 27 weeks and 31 gestation. Mother had been alloimmunized anti-D anti-C antibodies. At birth, laboratory investigations revealed bone marrow suppression along hemolytic anemia. The neonate started on a combination phototherapy intravenous immunoglobulin. During the course, transfused one unit packed red cells (top-up transfusion). Neonatal hyperbilirubinemia responded to activity spontaneously resumed after 3 life. In...
<p>This file contains 16 Supplemental tables and 14 Figures, as well numerous NMR traces, synthetic chemistry schemes, mass spectra, tables, multiple graphics related to gene expression profiles, dose response curves, x-ray structures, westerns, etc.</p>
<div>Abstract<p>Inhibition of members the bromodomain and extraterminal (BET) family proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 BD2) that are necessary recognition acetylated lysine residues in N-terminal regions histones. Chemical matter targets (BETi) also interact via these domains. Molecular cellular data indicate BD2 have different biological roles depending upon their context, with particularly...
<p>This file contains 16 Supplemental tables and 14 Figures, as well numerous NMR traces, synthetic chemistry schemes, mass spectra, tables, multiple graphics related to gene expression profiles, dose response curves, x-ray structures, westerns, etc.</p>