words constitute nearly half of the human lexicon and are critically associated with abstract thoughts, yet little is known about how they represented in brain. We tested neural basis 2 classical cognitive notions meaning representation: by linguistic contexts semantic features. collected fMRI BOLD responses for 360 built theoretical representational models from state-of-the-art corpus-based natural language processing behavioral ratings Representational similarity analyses revealed that...

China is implementing the family doctor (FD) system to reform primary healthcare (PHC). The contract service (FDCS) policy plays a crucial role in this implementation, aiming transform doctor-patient relationship and enhance PHC quality. This study aims investigate impact of FDCS on PHCs using field research methodology.

Abstract How do we represent information without sensory features? are abstract concepts like “freedom”, devoid of external perceptible referents, represented in the brain? Here, to address role neural representation concepts, used fMRI investigate how people born blind process whose referents imperceptible them because their visual nature (“rainbow”, “red”). Activity for these was compared that sensorially-perceptible (“rain”), classical (“justice”) and concrete (“cup”), providing a...

Concepts can be related in many ways. They belong to the same taxonomic category (e.g., "doctor" and "teacher," both of people) or associated with event context "stethoscope," medical scenarios). How are these two major types semantic relations coded brain? We constructed stimuli from three categories (people, manmade objects, locations) thematic (school, medicine, sports) investigated neural representations dimensions using representational similarity analyses human participants (10 men...

Classical animal visual deprivation studies and human neuroimaging have shown that experience plays a critical role in shaping the functionality connectivity of cortex. Interestingly, recent additionally reported circumscribed regions cortex which functional selectivity was remarkably similar individuals with without experience. Here, by directly comparing resting-state task-based fMRI data congenitally blind sighted subjects, we obtained large-scale continuous maps degree to connectional...

Neuroimaging studies have consistently indicated that semantic processing involves a brain network consisting of multimodal cortical regions distributed in the frontal, parietal, and temporal lobes. However, little is known about how information organized processed within network. Some recent sensory–motor modulates activation this Other responds more to social than other information. Using fMRI, we collectively investigated activations evoked by manipulating sociality imageability verbs...

Primary visual cortex (V1) is generally thought of as a low-level sensory area that primarily processes basic features. Although there evidence for multisensory effects on its activity, these are typically found the processing simple sounds and their properties, example spatially or temporally-congruent sounds. However, in congenitally blind individuals, V1 involved language processing, with no major changes anatomical connectivity could explain this seemingly drastic functional change. This...

Spatial working memory (SWM) is an important component of and plays essential role in driving high-level cognitive abilities. Recent studies have demonstrated that individual SWM associated with global brain communication. However, whether specific network nodal connectivity, such as hub involved performances remains largely unknown. Here, we collected resting-state fMRI (R-fMRI) data from a large group 130 young healthy participants evaluated their performances. A voxel-wise whole-brain...

Abstract Primary visual cortex (V1) is generally thought of as a low-level sensory area that primarily processes basic features. However, in congenitally blind individuals, V1 involved language processing, with no evidence major changes anatomical connectivity could explain this seemingly drastic functional change. This at odds current accounts neural plasticity, which emphasize the role and conserved function determining tissue’s even after atypical early experiences. To reconcile what...

Visual cortex organization is highly consistent across individuals. But to what degree does this consistency depend on life experience, in particular sensory experience? In study, we asked whether visual reorganization congenital blindness results connectivity patterns that are particularly variable individuals, focusing resting-state functional (RSFC) from the primary cortex. We show absence of shared experience more RSFC blind individuals than sighted controls. Increased variability...

To investigate the association between diabetes knowledge and self-management (DSM) behaviors to explore influence mechanism them among patients with type 2 mellitus (T2DM) based on health belief model in rural China.This cross-sectional study included 483 participants T2DM from 8 villages of 3 townships Jiangsu Province. All completed a structured questionnaire, including demographic information, knowledge, DSM behaviors, beliefs, cognitive function. Multiple linear regression mediation...

Abstract A critical way for humans to acquire information is through language, yet whether and how language experience drives specific neural semantic representations still poorly understood. We considered statistical properties captured by 3 different computational principles of (simple co-occurrence, network-(graph)-topological relations, neural-network-vector-embedding relations) tested the extent which they can explain patterns representations, measured 2 functional magnetic resonance...

How world knowledge is stored in the human brain a central question cognitive neuroscience. Object effects have been commonly observed higher-order sensory association cortices, with role of language being highly debated. Using object color as test case, we investigated whether communication system plays necessary neural representation visual cortex and corresponding behaviors, combining diffusion imaging (measuring white-matter structural integrity), functional MRI (fMRI; measuring...

Human ventral occipital temporal cortex contains clusters of neurons that show domain-preferring responses during visual perception. Recent studies have reported some these surprisingly similar domain selectivity in congenitally blind participants performing nonvisual tasks. An important open question is whether functional similarities are driven by innate connections and sighted groups. Here we addressed this focusing on the parahippocampal gyrus (PHG), a region selective for large objects...

Famous places and famous people are different from their common counterparts in that we have unique knowledge about individual items, including specific visual appearance other sensory properties. Previous studies shown the processing of entities selectively activates a network brain regions includes bilateral anterior temporal lobes (ATL), posterior cingulate cortex adjacent medial precuneus (PCC/medPrec), prefrontal (medPFC), temporal-parietal junction (TPJ). The degree to which these...

Surface plasmon resonance (SPR) has been well established as a method of choice for label-free kinetic measurements biomolecular interactions. The conventional approach involves multiple injections an analyte different concentrations into fluidic channel covered with fixed ligand density. Optimization the experimental conditions and assessment data quality can be complicated by issues such disruption structure regeneration step limited availability sample solution. By sequentially closing...