A5101437749- Genetics, Aging, and Longevity in Model Organisms
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Dendrimers and Hyperbranched Polymers
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Glutathione Transferases and Polymorphisms
- Supramolecular Self-Assembly in Materials
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Arsenic contamination and mitigation
- Advanced Drug Delivery Systems
- Heavy metals in environment
- Mitochondrial Function and Pathology
- Inflammatory mediators and NSAID effects
- Air Quality and Health Impacts
- melanin and skin pigmentation
- Traditional Chinese Medicine Analysis
- Reproductive Biology and Fertility
University of California, Riverside
2020-2025
Chinese Academy of Sciences
2015-2019
Hefei Institutes of Physical Science
2015-2019
Hefei University
2017-2019
University of Science and Technology of China
2018
Anhui University of Traditional Chinese Medicine
2017
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2010-2011
National Institutes of Health
2010-2011
Wayne State University
2008-2011
Children's Hospital of Michigan
2010-2011
Abstract Microsatellite repeat expansions within genes contribute to a number of neurological diseases 1,2 . The accumulation toxic proteins and RNA molecules with repetitive sequences, and/or sequestration RNA-binding by containing expanded repeats are thought be important contributors disease aetiology 3–9 Here we reveal that the adenosine in CAG can methylated N 1 -methyladenosine (m A) TRMT61A, m A demethylated ALKBH3. We also observed A/adenosine ratio increases length, which is...
Aim: Understanding the interactions between nanomaterials and disease processes is crucial for designing effective therapeutic approaches. This article explores unusual neuroinflammation targeting of dendrimers (with no ligands) in brain, with significant consequences nanoscale materials medicine. Method: The vivo biodistribution fluorescent-labeled neutral generation-4- polyamidoamine (∼4 nm) a rabbit model cerebral palsy was explored following subarachnoid administration. Results: These...
Local intravaginal drug therapy is preferred for treatment of ascending genital infections during pregnancy. In the present study, an in situ forming biodegradable hydrogel sustained release amoxicillin cervicovaginal region described. A generation 4 poly(amidoamine) [G4-(NH(2))(64)] dendrimer with peripheral thiopyridyl terminations cross-linked 8-arm polyethylene glycol (PEG) bearing thiol terminations. The hydrogels were formulated and tested vivo a pregnant guinea pig model volume,...
Graphene oxide (GO), owing to its large surface area and abundance of oxygen-containing functional groups, is emerging as a potential adsorbent for polychlorinated biphenyls (PCBs), which accumulate over time are harmful both natural ecosystems human health. However, the effect GO against PCB-induced toxicity remains largely unexplored. The present study aimed investigate protective PCB 52 induced cytotoxic genotoxic response in mammalian cells at various exposure conditions clarify role...
Endosulfan is enlisted as one of the persistent organic pollutants (POPs) and exists in form its α β isomers environment well endosulfan sulfate, a toxic metabolite. General toxicity has been investigated various organisms, but effect sulfate metabolites on reproductive function unclear. This study was aimed at studying dysfunction induced by metabolite Caenorhabditis elegans (C. elegans). We also determined role for DNA-damage-checkpoint gene hus-1. Compared to β-endosulfan metabolite,...
Endosulfan as a new member of persistent organic pollutants has been shown to induce reproductive dysfunction in various animal models. However, the action mechanism endosulfan-produced toxicity remains largely unknown. This study was focused on investigating induced by α-endosulfan and clarifying role mitochondria genotoxic response genes germ cell apoptosis Caenorhabditis elegans. Our data showed that endosulfan dose-dependent decrease life span, fecundity, hatchability, whereas...
ABSTRACT Nucleotide repeat expansions contribute to the development of a number neurodegenerative diseases. Recent studies revealed that DNA sequences with CAG and other nucleotide can undergo bidirectional transcription, ensuing transcripts could be translated into proteins through repeat‐associated non‐AUG (RAN) translation; however, not much is known about precise mechanisms underlying RAN translation. Here, we demonstrated m 6 A, installed by METTL3 removed FTO, promotes translation in...
Despite treatment of lung cancer with radiotherapy and chemotherapy, the survival rate patients remains poor. Previous studies demonstrated importance upregulation inflammatory factors, such as cyclooxygenase 2 (cox2), in tumor tolerance. In present study, we investigated role cox2 radiosensitivity cancer. Our results showed that combination radiation aspirin, an anti-inflammatory drug, induced a synergistic reduction cell A549 H1299 cells. comparison normal human fibroblasts (NHLFs),...
This study provided new evidence for how nanoparticles affect multigenerational transfer and toxicity of cadmium.
To extend the applications of engineered nanomaterials, such as graphene oxide (GO), it is necessary to minimize cytotoxicity. However, mechanisms underlying this cytotoxicity are unclear. Dynamic chromosomal interactions have been used illustrate molecular bases gene expression, which offers a more sensitive and cutting-edge technology elucidate complex biological processes associated with epigenetic regulations. In study, role GO-triggered chromatin in activation cox2, hallmark...
The mechanism of GO-decreased As(<sc>iii</sc>) toxicity.
Our data provide the direct<italic>in vivo</italic>evidence to indicate molecular signalling mechanism of endosulfan-induced apoptosis.