A5057209422- Heart Failure Treatment and Management
- Lung Cancer Treatments and Mutations
- Healthcare Policy and Management
- Cardiovascular Function and Risk Factors
- Lung Cancer Research Studies
- Coronary Interventions and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Primary Care and Health Outcomes
- Head and Neck Cancer Studies
- Cardiac Valve Diseases and Treatments
- Testicular diseases and treatments
- Management of metastatic bone disease
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Global Health Care Issues
- Peripheral Artery Disease Management
- Ovarian cancer diagnosis and treatment
- Viral Infections and Immunology Research
- Cancer Genomics and Diagnostics
- Cardiac Structural Anomalies and Repair
- Neurogenesis and neuroplasticity mechanisms
- Biomarkers in Disease Mechanisms
- Kawasaki Disease and Coronary Complications
- Emergency and Acute Care Studies
- Food Security and Health in Diverse Populations
Harvard University
2015-2024
Beth Israel Deaconess Medical Center
2019-2024
CSL (United States)
2024
Baim Institute for Clinical Research
2024
Massachusetts General Hospital
2018-2023
Cardiovascular Research Associates
2022
Beth Israel Deaconess Hospital
2021
Lemuel Shattuck Hospital
2015-2021
Deaconess Hospital
2019-2020
Memorial Sloan Kettering Cancer Center
2015
Purpose Advanced anaplastic lymphoma kinase ( ALK) fusion-positive non-small-cell lung cancers (NSCLCs) are effectively treated with ALK tyrosine inhibitors (TKIs). However, clinical outcomes in these patients vary, and the benefit of TKIs is limited as a result acquired resistance. Emerging data suggest that fusion variant may affect outcome, but molecular basis for this association unknown. Patients Methods We identified 129 ALK-positive NSCLC known variants. resistance mutations on were...
<h3>Importance</h3> Cardiovascular disease is a major cause of death among homeless adults, with mortality rates that are substantially higher than in the general population. It unknown whether differences hospitalization-related care contribute to these disparities cardiovascular outcomes. <h3>Objective</h3> To evaluate intensity and between nonhomeless individuals hospitalized for conditions (ie, acute myocardial infarction, stroke, cardiac arrest, or heart failure). <h3>Design, Setting,...
Purpose Targeted therapy is the cornerstone of treatment advanced EGFR-mutant non–small-cell lung cancer (NSCLC). Next-generation sequencing (NGS), preferred method for genotyping, typically requires several weeks. Here, we assessed workflows designed to rapidly identify patients with actionable EGFR mutations and reduce time initiation (TTI) epidermal growth factor receptor (EGFR)–directed therapy. Patients Methods We performed rapid testing L858R exon 19 deletions on paraffin-embedded or...
This study aimed to report response rates and predictors of palliative radiotherapy (RT) for recurrent ovarian cancer.Database review identified 64 patients with symptomatic cancer recurrence who received a total 76 courses RT 103 indications from March 2003 August 2014. Radiotherapy were pain (44%), bleeding (32%), obstruction (15%), other (9%). Responses categorized as complete, partial, or none; all (AR) was the sum complete partial responses. Response compared using χ test. Multivariate...
<h3>Importance</h3> The US Centers for Medicare & Medicaid Services have implemented national value-based programs that incentivize hospitals to deliver better cardiovascular care. However, it is unclear how recognized high-quality care by American Heart Association (AHA) and College of Cardiology (ACC) quality improvement initiatives (termed<i>award hospitals</i>) performed under programs. <h3>Objective</h3> To determine if received awards from the AHA/ACC were less likely be penalized...
Severe cardiac sarcoidosis (CS) can share clinical and histopathologic features with giant cell myocarditis (GCM).A 56-year-old female presented 1 week of exertional chest pressure dyspnoea. Echocardiogram demonstrated extensive regional dysfunction left ventricular ejection fraction (LVEF) 38%. Cardiac catheterization revealed no obstructive coronary artery disease index 1.5 L/min/m2. magnetic resonance imaging (MRI) diffuse late gadolinium enhancement. Positron emission tomography...
Background: Inflammation has been implicated in the pathogenesis of acute coronary syndrome (ACS). The comparative performance blood cell-based inflammatory markers mortality prediction among ACS patients remains unclear. Methods: In this multinational, double-blind, phase 2 trial, with recent were randomized to receive rivaroxaban or a placebo. relationship (including neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte [PLR], lymphocyte-to-monocyte [LMR], systemic...
Background: Multivessel disease (MVD) heightens the risk of major adverse cardiovascular events (MACE) in post-myocardial infarction (MI) patients. The MACE is elevated early period after an MI, a unaddressed by current secondary preventative therapies. Research aims: To better understand impact MVD on clinical and patient-centered outcomes post-MI treatment landscape. Methods: A systematic literature review was conducted to identify relevant articles published between March 2019 July 2022...