A5037198003- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Air Quality Monitoring and Forecasting
- Respiratory Support and Mechanisms
- Advanced Chemical Sensor Technologies
- Non-Invasive Vital Sign Monitoring
- Bluetooth and Wireless Communication Technologies
- Anesthesia and Sedative Agents
- Microfluidic and Capillary Electrophoresis Applications
Fraunhofer Institute for Toxicology and Experimental Medicine
2020-2022
Abstract The growing use of 3D printing in the biomedical sciences demonstrates its utility for a wide range research and healthcare applications, including potential implementation discipline breath analysis to overcome current limitations substantial costs commercial sampling interfaces. This technical note reports on design construction 3D-printed mouthpiece adapter exhaled using respiration collector in-vitro (ReCIVA) device. paper presents digital workflow transition fabrication from...
A major disadvantage of inhalation therapy with continuous drug delivery is the loss medication during expiration. Developing a breath-triggered release system can highly decrease this loss. However, there currently no directly inside patient interface (nasal prong) for preterm neonates available due to their high breathing frequency, short inspiration time and low tidal volume. Therefore, nasal prong an integrated valve releasing aerosol increasing inhaled efficiency desirable. We...
In order to deliver an aerosolized drug in a breath-triggered manner, the initiation of patient’s inspiration needs be detected. The best-known systems monitoring breathing patterns are based on flow sensors. However, due their large dead space volume, sensors not advisable for (preterm) neonates. Newly-developed respiratory sensors, especially when contact-based (invasive), can tested neonates only with great effort clinical and ethical hurdles. Therefore, physiological model is highly...
Background: Developing new (triggered) or improving existing inhaler systems for (preterm) neonates and adults requires test benches the determination of aerosol output rate. Furthermore, real-time measurement rate is advantageous with respect to both development costs time, especially when using liquid humidified dry aerosols. The current standard procedures following ISO 27427, however, are time-consuming. Moreover, these not applicable inhalers preterm neonates, due their high breathing...