A5046185218- Hormonal Regulation and Hypertension
- Sphingolipid Metabolism and Signaling
- Signaling Pathways in Disease
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Protein Degradation and Inhibitors
University of California, Berkeley
2017-2021
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced resistance was attenuated upon ablation
Chronic glucocorticoid exposure causes insulin resistance and muscle atrophy in skeletal muscle. We previously identified phosphoinositide-3-kinase regulatory subunit 1 (Pik3r1) as a primary target gene of receptors involved the glucocorticoid-mediated suppression action. However, vivo functions Pik3r1 remain unclear. Here, we generated striated muscle-specific knockout (MKO) mice treated them with dexamethasone (DEX), synthetic glucocorticoid. Treating wildtype (WT) DEX attenuated activated...