A5037412656- Animal Virus Infections Studies
- Aquaculture disease management and microbiota
- Viral Infections and Vectors
- Virus-based gene therapy research
- Invertebrate Immune Response Mechanisms
- Viral gastroenteritis research and epidemiology
University of Copenhagen
2021
Technical University of Denmark
2021
The rapidly increasing Mediterranean aquaculture production of European sea bass is compromised by outbreaks viral nervous necrosis, which can be recurrent and detrimental. In this study, we evaluated the duration protection immune response in given a single dose virus-like particle (VLP)-based vaccine. Examinations included experimental challenge with necrosis virus (NNV), serological assays for NNV-specific antibody reactivity, gene expression analysis. VLP-vaccinated fish showed high...
Viral Nervous Necrosis (VNN, also called viral encephalo- and retinopathy (VER)), is a widespread disease of marine aquaculture caused by betanodavirus (or nervous necrosis virus - NNV), segmented positive sense RNA virus, member the nodaviridae family. VNN affects predominantly fish cause significant losses to Mediterranean farming industry, including production European sea bass (Dicentrarchus labrax). Of four circulating genotypes betanodavirus, red-spotted grouper NNV (RGNNV) reassortant...
Viral Nervous Necrosis (VNN) causes high mortality and reduced growth in farmed European sea bass (Dicentrarchus labrax) the Mediterranean. In current studies, we tested a novel Pichia-produced virus-like particle (VLP) vaccine against VNN bass, caused by betanodavirus “Red-Spotted Grouper Virus” (RGNNV). were immunized with VLP-based formulated different concentrations of antigen or without adjuvant. Antibody response was evaluated ELISA serum neutralization. The efficacy these VLP-vaccine...
Diarrhea in mink kits is a major cause of disease and mortality the production. The etiology remains unknown most outbreaks due to lack diagnostic assays. In current study we present an RT-qPCR method detect astrovirus fecal samples from with diarrhea. All sampled animals were classified based on age patoanatomical evaluation as having pre-weaning diarrhea, diarrhea growth period or no macroscopic signs Fecal analyzed for MiAstV RT-qPCR, next generation sequencing electron microscopy...