A5053362360- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Bee Products Chemical Analysis
- Pomegranate: compositions and health benefits
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Biochemical and Molecular Research
- Extracellular vesicles in disease
- vaccines and immunoinformatics approaches
- Genetics and Neurodevelopmental Disorders
- Respiratory viral infections research
- Medical and Biological Ozone Research
Gebze Technical University
2022-2023
TÜBİTAK Marmara Research Center
2022-2023
Scientific and Technological Research Council of Turkey
2022
Prevention of COVID-19 is paramount importance for public health. Some natural extracts might have the potential to suppress infection. Therefore, this study aimed design a standardised, efficient, and safe chewable tablet formulation (with propolis three herbal extracts) possible prevention against two variants (Wuhan B.1.36 Omicron BA.1.1) SARS-CoV-2 virus other viral infections. Green tea, bilberry, dried pomegranate peel, were selected purpose. Cytotoxicity antiviral activity each...
The purpose of this study was to look into the antiviral activity a plant extract derived from roots Saussurea lappa as food supplement against SARS-CoV-2 infection.Vero E6 cells are employed in test neutralizing effect virus. For anti-viral detection, sensitive real-time cell analyzer (xCELLigence RTCA) with high repetition rate is used. A challenge experiment mice planned result vitro analysis. performed 10 adult female K18-hACE2 transgenic each group for purpose. S. Group gavaged 2 days...
The scale of the COVID-19 pandemic forced urgent measures for development new therapeutics. One these strategies is use convalescent plasma (CP) as a conventional source passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present structural, biochemical, and biological characterization our proprietary product, human immune plasma-derived exosome (ChipEXO), following guidelines set forth by Turkish Ministry Health Red Crescent, Good Manufacturing...
A broad range of evidence has confirmed that natural products and essential oils might have the potential to suppress COVID-19 infection. Therefore, this study aimed develop an oral/throat spray formulation for prophylactic use in oral cavity or help treatment modalities. Based on a reference survey, several oils, cold-pressed oil, propolis were selected, cytotoxicity antiviral activity each component developed examined against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)...
Favipiravir, an RNA-dependent RNA polymerase (RdRp) inhibitor, is used to treat patients infected with influenza virus and most recently SARS-CoV-2. However, poor accumulation of favipiravir in lung tissue following oral administration has required alternative method that directly targets the lungs. In this study, inhalation solution at a concentration 2 mg mL-1 was developed characterized for first time. The chemical stability inhaled two different media, phosphate buffer saline (PBS)...
Coiled-coil domain-containing protein-124 (Ccdc124) is a conserved eukaryotic ribosome-associated RNA-binding protein which involved in resuming ribosome activity after stress-related translational shutdown. Ccdc124 also detected at cellular localizations devoid of ribosomes, such as the centrosome, or cytokinetic midbody, but its translation-independent function currently unknown.