A5087572255- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
University of Oxford
2022-2023
Certain inhibitor of apoptosis (IAP) family members are sentinel proteins that prevent untimely cell death by inhibiting caspases. Antagonists, including second mitochondria-derived activator caspases (SMAC), regulate IAPs and drive death. Baculoviral IAP repeat-containing protein 6 (BIRC6), a giant with dual E2 E3 ubiquitin ligase activity, regulates programmed through unknown mechanisms. We show BIRC6 directly restricts executioner caspase-3 -7 ubiquitinates caspase-3, -7, -9, working...
ABSTRACT Apoptosis, a form of genetically programmed cell death, can be triggered by either internal or external signals ultimately activating caspases, family proteases 1 . Certain members the inhibitors apoptosis (IAP) are sentinel proteins preventing untimely death inhibiting caspases. IAPs in turn regulated antagonists including second mitochondria-derived activator caspase (SMAC). Baculoviral IAP repeat-containing protein 6 (BIRC6), giant IAP, possesses dual E2/E3 ubiquitin ligase...