A5089344885- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- AI in cancer detection
- Breast Implant and Reconstruction
- Optical Imaging and Spectroscopy Techniques
- Venous Thromboembolism Diagnosis and Management
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- COVID-19 and healthcare impacts
- Head and Neck Anomalies
- Radiation Dose and Imaging
- Cell Adhesion Molecules Research
- Mercury impact and mitigation studies
- Thyroid Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Nasolacrimal Duct Obstruction Treatments
- Ultrasound Imaging and Elastography
- Health Literacy and Information Accessibility
- Infectious Diseases and Tuberculosis
- Oropharyngeal Anatomy and Pathologies
- Dermatologic Treatments and Research
Royal Lancaster Infirmary
2020-2022
University Hospitals of Morecambe Bay NHS Foundation Trust
2020-2021
King's College Hospital
2019
West Middlesex University Hospital
2008-2018
University College London
2008-2018
The Royal Free Hospital
2008-2012
Royal Free London NHS Foundation Trust
2012
National University of Malaysia
2004-2010
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2007
Madurai Medical College
1991
Abstract Background Temporal artery biopsy (TAB) is considered the gold standard for diagnosing Giant Cell Arteritis (GCA). The aim of this study was to compare functional utility 2016 revised ACR (rACR) criteria against original with a view avoiding TABs in select groups. We also aimed investigate temporal relationship positive biopsies. Methods A retrospective conducted patients undergoing TAB from August 2014 2016, at DGH. Data collected included patient demographics, history,...
Abstract Background Wire localization is historically the most common method for guiding excision of non-palpable breast lesions, but there are limitations to technique. Newer technologies such as magnetic seeds may allow some these challenges be overcome. The aim was compare safety and effectiveness wire seed techniques. Methods Women undergoing standard or lesions between August 2018 2020 were recruited prospectively this IDEAL stage 2a/2b platform cohort study. primary outcome defined...
Abstract Background Intraoperative diagnosis of sentinel node metastases enables an immediate decision to proceed axillary lymph dissection, avoiding a second operation in node-positive women with breast cancer. Methods An optical scanner was developed that interrogated the cut surface bivalved, but otherwise unprocessed, nodes pulses white light by elastic scattering spectroscopy (ESS). The scattered underwent spectral analysis, and individual spectra were initially correlated conventional...
A novel method for rapidly detecting metastatic breast cancer within excised sentinel lymph node(s) of the axilla is presented. Elastic scattering spectroscopy (ESS) a point-contact technique that collects broadband optical spectra sensitive to absorption and tissue. statistical discrimination algorithm was generated from training set nearly 3000 clinical used test collected an independent nodes. Freshly nodes were bivalved mounted under fiber-optic plate. Stepper motors raster-scanned probe...
Sentinel lymph node biopsy is a standard diagnosis procedure to determine whether breast cancer has spread the glands in armpit (the axillary nodes). The metastatic status of sentinel first chain that drains affected breast) determining factor surgery between conservative lumpectomy and more radical mastectomy including excision. traditional assessment requires sample preparation pathologist interpretation. An automated elastic scattering spectroscopy (ESS) scanning device was constructed...
Background Sentinel lymph node biopsy (SLNB) is the current standard of care for lymphatic staging in early breast cancer patients. The combination a SLNB with an intra-operative diagnosis enables single staged procedure, avoiding delayed axillary dissection (ALND) positive conventional pathological techniques are resource intensive, require expert personnel and not routinely used many units. Methods GeneSearch™ BLN assay RT-PCR technique calibrated to detect SLN metastases >0.2mm. It...
A method has been developed for the analysis of images sentinel lymph nodes generated by a spectral scanning device. The aim is to classify nodes, excised during surgery breast cancer, as normal or metastatic. data from one node constitute spectra at 86 wavelengths each pixel 20*20 grid. For analysis, are reduced scores on two factors, derived externally linear discriminant using taken manually known and metastatic tissue, under investigation capture variability orthogonal external factor....
Sentinel Node biopsy is a clinical technique for detecting metastatic spread in breast cancer. We demonstrate how Elastic Scattering Spectroscopy scanning sensitive to malignant morphological changes and can be used rapid intraoperative diagnosis.