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Leah V. Chifamba

ORCID: 0000-0003-0807-5069
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A5117189127
Research Areas
  • Neonatal Health and Biochemistry
 Lack of association between G6PD and Parkinson's disease
OPENALEX - Publications 
Leah V. Chifamba Sitki Cem Parlar Eric Yu A. Asayesh Jamil Ahmad and 21 more Jennifer A. Ruskey Dan Spiegelman Aliza Dworkind Cheryl Waters Stanley Fahn Oury Monchi Yves Dauvilliers Nicolas Dupré Lior Greenbaum Sharon Hassin‐Baer А. V. Tyurin Ilya O. Nagornov Alla Timofeeva Irina Miliukhina Mariia Beletskaia Alexander Emelyanov С. Н. Пчелина Ekaterina Yur'evna Zakharova Roy N. Alcalay Konstantin Senkevich Ziv Gan‐Or

10.1016/j.parkreldis.2025.107398 article EN Parkinsonism & Related Disorders 2025-04-17
 Lack of association between G6PD variants and Parkinson's disease
OPENALEX - Publications 
Leah V. Chifamba Sitki Cem Parlar L W Liu Leonard L. Sokol Eric Yu and 18 more Farnaz Asayesh Jamil Ahmad Jennifer A. Ruskey Dan Spiegelman Cheryl Waters Oury Monchi Yves Dauvilliers Nicolas Dupré Alla Timofeeva Anton Emelyanov Sofya Pchelina Irina Miliukhina Lior Greenbaum Sharon Hassin‐Baer Roy N. Alcalay Alberto J. Espay Ziv Gan‐Or Konstantin Senkevich

Oxidative stress has been implicated in Parkinson's disease (PD). Genes involved PD, such as PRKN, PINK1 and PARK7, contribute to oxidative dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase, an important regulator of stress. Recent studies suggested that alpha-synuclein aggregates may impair activity neuron loss, mutations independently increase the risk PD. In this study, we aimed examine role common rare variants PD across six cohorts including 8,905...

10.1101/2025.04.23.25324774 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2025-04-25
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