A5101570297- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Telemedicine and Telehealth Implementation
- Iron Metabolism and Disorders
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Erythropoietin and Anemia Treatment
- Hemoglobin structure and function
- Methemoglobinemia and Tumor Lysis Syndrome
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hepatitis B Virus Studies
- COVID-19 diagnosis using AI
- Blood transfusion and management
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2023
Fondazione Bruno Kessler
2020-2021
Ospedale Maggiore
1996-2008
Istituti di Ricovero e Cura a Carattere Scientifico
1999-2003
Policlinico Universitario di Catania
1991
Clinical and serological data on 1435 Italian thalassemia major patients were collected during a cooperative study involving 19 centers in 10 regions. The main findings as follows: 18 percent of the under 6 years age, 63 between 15, over 15. Forty‐one had undergone splenectomy. Sixty‐two maintained at pretransfusion hemoglobin levels higher than g per dl, 36 8 2 below dl. Overall, 5.2 clinically significant red cell alloantibodies (136 74 patients). One‐half immunized more one one‐fourth two...
Background Italy was the first country to largely experience COVID-19 epidemic among other Western countries during so-called wave of pandemic. Proper management an increasing number home-quarantined individuals created a significant challenge for health care authorities and professionals. This especially true when considering importance remote surveillance detect signs disease progression consequently regulate access hospitals intensive units on priority basis. Objective In this paper, we...
Two siblings of Italian origin with mild chronic haemolytic anaemia, psychomotor impairment and undetectable adenylate kinase (AK) activity are reported. The other red cell enzyme activities were normal except for a slight decrease PFK. 2,3‐DPG levels increased in both siblings, AMP decreased one only. parents not consanguineous displayed intermediate AK activity. sequence complete erythrocyte AK‐1 cDNA showed the presence nonsense homozygous mutation at codon 107 (CGA → TGA, Arg Stop)...
Summary. Pyrimidine 5′‐nucleotidase deficiency is a rare autosomal recessive disorder characterized by haemolytic anaemia, marked basophilic stippling and accumulation of pyrimidine nucleotides within the erythrocytes. The gene encoding for this enzyme ( P5′N‐1 ) has been cloned recently, seven mutations have so far identified in 11 unrelated families. We describe haematological molecular characteristics six Italian patients affected (one from northern five southern Italy). sequence complete...
A compensated haemolytic state is defined by decreased red cell life‐span without anaemia, i.e. increased erythropoiesis in the absence of physiological stimulus for erythropoietin (Epo) production. We evaluated s‐Epo levels and expansion (as measured circulating transferrin receptor, s‐TfR) 32 patients with hereditary spherocytosis (HS) aim verifying whether enhanced haemolysis was Epo‐dependent. 20 (62.5%) had normal Hb values (> 12 g/dl females > 13 males). Their result up to 8.2...
<sec> <title>BACKGROUND</title> Italy was the first country to largely experience COVID-19 epidemic among other Western countries during so-called wave of pandemic. Proper management an increasing number home-quarantined individuals created a significant challenge for health care authorities and professionals. This especially true when considering importance remote surveillance detect signs disease progression consequently regulate access hospitals intensive units on priority basis. </sec>...