A5021709083- Cancer-related Molecular Pathways
- Reproductive biology and impacts on aquatic species
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Prion Diseases and Protein Misfolding
- History and advancements in chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- HIV Research and Treatment
- Click Chemistry and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chemical Synthesis and Analysis
- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- Chemistry and Chemical Engineering
- RNA regulation and disease
- Sperm and Testicular Function
- Advanced biosensing and bioanalysis techniques
- Aquaculture Nutrition and Growth
- RNA modifications and cancer
- Various Chemistry Research Topics
- Computational Drug Discovery Methods
New York University
2025
New York University Abu Dhabi
2016-2022
Wilfrid Laurier University
2012
Abstract Missense mutations in p53 are severely deleterious and occur over 50% of all human cancers. The majority these located the inherently unstable DNA-binding domain (DBD), many which destabilize further expose its aggregation-prone hydrophobic core, prompting self-assembly mutant into inactive cytosolic amyloid-like aggregates. Screening an oligopyridylamide library, previously shown to inhibit amyloid formation associated with Alzheimer’s disease type II diabetes, identified a...
The conversion of the native random coil amyloid beta (Aβ) into fibers is thought to be a key event in progression Alzheimer's disease (AD). A significant body evidence suggests that highly dynamic Aβ oligomers are main causal agent associated with onset AD. Among many potential therapeutic approaches, one modulation conformation off-pathway structures avoid formation putative neurotoxic oligomers. library oligoquinolines was screened identify antagonists oligomerization, formation, and...
It is extremely advantageous to detect nucleic acid levels in the early phases of disease management; such detection facilitates timely treatment, and it can prevent altogether certain cancers infectious diseases. A simple, rapid, versatile platform without enzymatic amplification for both short long sequences would be highly desirable this regard. Our study addresses need by introducing IMACC, an ICP-based Microfluidic Accelerator Combined with CRISPR, amplification-free detection. exploits...
The research-driven laboratory experiment described herein has at its core the individual development of students, combining subject matter with opportunity to explore, in a research environment, areas outside traditional curricula; however, it maintains pedagogical training for an undergraduate major degree chemistry and sciences general. can feasibly be implemented high schools expose students engaging intellectually fulfilling aspect early their career. This seven-week project is based on...
ABSTRACT Missense mutations in p53 are severely deleterious and occur over 50% of all human cancers. The vast majority these located the inherently unstable DNA-binding domain (DBD), many which destabilize further expose its aggregation-prone hydrophobic core, prompting self-assembly mutant into inactive cytosolic amyloid-like aggregates. Screening an oligopyridylamide library, previously shown to inhibit amyloid formation associated with Alzheimer’s disease type II diabetes, identified a...