A5061937767- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Osteoarthritis Treatment and Mechanisms
- Impact of Light on Environment and Health
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- Pharmaceutical studies and practices
- Urban Transport and Accessibility
- Analytical Methods in Pharmaceuticals
- Genomics and Chromatin Dynamics
- Drug Solubulity and Delivery Systems
- Nerve injury and regeneration
- Ubiquitin and proteasome pathways
- Nuclear Receptors and Signaling
- Gene Regulatory Network Analysis
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Mesenchymal stem cell research
- Smart Parking Systems Research
- Gene expression and cancer classification
- Silk-based biomaterials and applications
Baylor College of Medicine
2012-2019
University of Pittsburgh
2017-2019
Dan L Duncan Comprehensive Cancer Center
2015
Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate functions mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, Signaling Pathways Project (SPP), which incorporates community classifications pathway nodes (receptors, enzymes, transcription factors co-nodes) their cognate bioactive small molecules. We then mapped over 10,000 or cistromic experiments to node biosample study. To...
An updated data-mining web tool enables researchers to understand how nuclear receptors affect genes or cellular processes of interest.
Signaling pathways involving nuclear receptors (NRs), their ligands and coregulators, regulate tissue-specific transcriptomes in diverse processes, including development, metabolism, reproduction, the immune response neuronal function, as well associated pathologies. The Nuclear Receptor Atlas (NURSA) is a Consortium focused around Hub website (www.nursa.org) that annotates integrates 'omics datasets originating from published literature NURSA-funded Data Source Projects (NDSPs). These are...
The nuclear receptor (NR) superfamily of ligand-regulated transcription factors directs ligand- and tissue-specific transcriptomes in myriad developmental, metabolic, immunological, reproductive processes. NR signaling field has generated a wealth genome-wide expression data points, but due to deficits their accessibility, annotation, integration, the full potential these studies not yet been realized. We searched public gene databases MEDLINE for global transcriptomic datasets relevant NRs,...
Roller compaction parameters' impact on granules and tableting properties of coprocessed Avicel® DG [ADG], a physical mixture the two components at same composition present in ADG [PADCP], microcrystalline cellulose Kollidon® VA-64 Fine [KVA64] was quantified by analysis variance (ANOVA) multivariate methods. force, roller gap, speed levels were selected for evaluation. A 33 full-factorial experimental design with three center points used. The response parameters studied granule-to-fines...
Abstract Integrated mining of public transcriptomic and ChIP-Seq datasets has the potential to illuminate facets mammalian cellular signaling pathways not yet explored in research literature. Here, we designed a web knowledgebase, Signaling Pathways Project (SPP), which incorporates stable community classifications four major categories pathway node (receptors, enzymes, transcription factors co-nodes) their cognate bioactive small molecules (BSMs). We then mapped over 10,000 or cistromic...