A5102736194- Macrophage Migration Inhibitory Factor
- Biochemical and Molecular Research
- Protein Tyrosine Phosphatases
- Click Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Inflammatory mediators and NSAID effects
- Palliative Care and End-of-Life Issues
- Fluorine in Organic Chemistry
- PI3K/AKT/mTOR signaling in cancer
- Cardiac tumors and thrombi
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Occupational and environmental lung diseases
- Synthesis of β-Lactam Compounds
- Medical Imaging and Pathology Studies
- CNS Lymphoma Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Multiple Myeloma Research and Treatments
- Palliative and Oncologic Care
Seoul Medical Center
2013-2024
Beth Israel Deaconess Medical Center
2024
Cancer Research Institute
2024
Harvard University
2024
National Cancer Center
2023
Sogang University
2012
Experts advise against parenteral nutrition (PN) for patients with advanced cancer at the end of life. But because many and families fear starvation, physicians administer PN to terminal in Korea.We designed this study investigate effect on survival life.We planned a randomized phase II enrolling 116 receive either fluid or PN.Eligible are who could not tolerate enteral feeding had short life expectancies (<3 months) due progressive cancer. Patients functioning bowels were excluded.The...
Objective To evaluate the compliance and satisfaction of rehabilitation recommendations for advanced cancer patients hospitalized in palliative care unit. Methods Advanced admitted to a hospice unit were recruited. Patients with life expectancy less than 6 months, as assumed by oncologist included. who expected die within 3 days excluded. ECOG Karnofsky performance scales, function ambulatory category, level ambulation, survival evaluated under perspective comprehensive rehabilitation....
We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma.Between October 1986 April 2013, 231 who were diagnosed liposarcoma by histologic examination enrolled in study.The distribution subtypes was well-differentiated (n = 97, 42%), myxoid 74, 32%), dedifferentiated 32, 13.9%), pleomorphic 15, 6.5%), round-cell 13, 5.6%). The majority liposarcomas located lower extremities (35.5%) retroperitoneum (34.2%). Prognosis worse for trunk group...
Well-differentiated papillary mesothelioma is an uncommon subtype of with a frequently indolent course, although it occasionally manifests in more aggressive form. To establish treatment strategy for this rare disease, we report the clinical characteristics and outcomes 15 patients well-differentiated mesothelioma.All pathologically diagnosed cases were reviewed between 1998 2012.Of cases, 8 7 presented single multiple lesions, respectively. All lesions asymptomatic, while 4 out symptomatic....
Central nervous system involvement remains a challenging issue in the treatment of patients with diffuse large B-cell lymphoma. We conducted prospective cohort study newly diagnosed lymphoma receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone to identify incidence risk factors for central involvement. Among 595 patients, 279 received pre-treatment evaluation, 14 had at diagnosis (2.3% out entire 5.0% patients). For those median follow-up duration was 38.2 months...
<b><i>Background:</i></b> HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will helpful understand the biological features of HER2-positive <b><i>Methods:</i></b> A total 813 cancer patients who underwent testing between January 2005 and December 2010 were included this study. <b><i>Results:</i></b> Ninety-five (11.7%) had Elevated serum carcinoembryonic antigen (CEA)...
The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). present study compared the effectiveness between IPI, NCCN-IPI, GELTAMO-IPI in DLBCL particularly terms determining high-risk patients. Among 439 who enrolled a prospective cohort treated R-CHOP immunochemotherapy, groups...
Background: Most patients and families do not want invasive life-sustaining procedures when recovery is unlikely. We compared the clinical features of advance directives (ADs) with without cancer. Methods: The ADs were obtained from retrospectively reviewing electronic medical records 699 consecutive who died April 2011 to July 2012. Results: Patients cancer more likely have written ADs: 265 (85.8%) 277 (71.0%) noncancer ( P < .001). Significantly in intensive care unit, indicating that...
The t(3;9)(q11–q12;q22) translocation associated with human extraskeletal myxoid chondrosarcomas results in a chimeric molecule which the N-terminal domain (NTD) of TFG ( T RK- f used g ene) is fused to TEC ranslocated E xtraskeletal C hondrosarcoma) gene. Little known about biological function TFG-TEC . Because NTDs and are structurally different, itself cytoplasmic protein, functional consequences this fusion were examined. showed that gene encoded nuclear protein bound DNA same sequence...
11552 Background: We conducted an open-label, phase IB/II study to determine the activity and safety of standard-of-care, doxorubicin in combined with anti-PD-L1 immune checkpoint inhibitor, durvalumab, patients anthracycline-naïve soft tissue sarcoma (STS) identified who would likely benefit from combination treatment. Methods: In this trial (NCT03798106), we enrolled metastatic and/or recurrent STS had not received anthracycline chemotherapy PD-L1/PD-1 inhibitor. Phase IB assessed...
Background: Patients and their family have resistance in withholding parenteral nutrition (PN) when patient become unable to intake food the end-of-life. We aimed investigate whether preference for PN is changed after receiving an individual education about risk benefit of PN. Additionally, we focused on preferences patients why they prefer it nutritional support end life. Methods: This prospective study. are eligible if cannot tolerate oral enteral feeding Palliative Performance Scale (PPS)...
Abstract We aimed to determine the activity of anti-VEGF receptor tyrosine-kinase inhibitor, pazopanib, combined with anti-PD-L1 durvalumab, in soft tissue sarcoma (STS). Further, we performed molecular characterisation whole exome and transcriptomic sequencing identify determinants response. In this single-arm, phase 2 trial (NCT#03798106), enrolled patients metastatic and/or recurrent STS who had received up two previous lines systemic anticancer therapy at least one measurable lesion....
Sparganosis is a rare parasitic infection caused by the plerocercoid of cestode Spirometra mansoni. The definitive hosts are dogs and cats, humans typically infected as aberrant hosts. clinical manifestations diverse most common symptom presents movable or fixed subcutaneous nodules. Differentiation sparganosis from soft tissue tumor skin metastasis in patient with cancer difficult; imaging finding lymphoma has rarely been reported (1, 2). We multimodal image findings including...
림프 아구성 림프종은 고도로 공격적인 성향을 띠는 림프종 의 아형으로, 비호지킨 림프종의 2% 미만을 차지한다. 이 중 90%가 T 세포 림프종이며, 질환의 70%가 전 종격동의 종괴로 발현되고, 흉수나 심낭 삼출액을 잘 동반한 다. 임상적으로 공격적이고 빠른 성장을 하기 때문에 호흡기 계 통의 응급을 초래하기도 한다. 항암치료에 반응하는 것으로 알려져 있으나, 약 25%의 환자에서 재발이 보고되고 있다. 질 환의 희귀성으로 인해 정확한 예후 예측에 어려움이 있지만, 일 반적으로 분화 속도가 빠르기 나쁜 예후를 가지는 것으 로 저자들은 짧은 기간 동안 급격한 크기 증가를 보였고, 3일간의 경험적 항암제 치료 후 감소를 보 인 젊은 남자에서 발생한 림프아구성 1예를 경험하여 이를 보고하고자 한다 증례 보고
e20504 Background: The incidence of venous thromboembolism (VTE) in advanced cancer patients is high. Analysis D-dimer concentration serves as a screening test for VTE due to its low cost and high sensitivity, although frequently elevated response other causes, such infection or malignancy. This study aimed evaluate the role patients. Methods: We retrospectively reviewed medical records from Hospice Palliative Care Center Seoul Medical July 2012 October 2013. Incurable exhibiting...
<div>Abstract<p>Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven unsuccessful. Here, we present a unique mouse model EGFR-driven gliomagenesis. We used combination somatic conditional ligand-mediated chronic activation cooperation with Ink4a/Arf central nervous system adult to generate tumors histopathologic...