A5102860253- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Health and Mental Health
- Climate Change and Health Impacts
- Congenital Heart Disease Studies
- Neuroscience of respiration and sleep
- Cardiovascular Issues in Pregnancy
- Coronary Interventions and Diagnostics
- Atmospheric chemistry and aerosols
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Air Quality and Health Impacts
- Cardiovascular Effects of Exercise
- Frailty in Older Adults
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
State Key Laboratory of Cardiovascular Disease
2023
Peking University
2019
Peking Union Medical College Hospital
2018
Abstract Background Lung cancer is the most common in China. Previous studies have indicated that lung incidence exhibits remarkable spatial heterogeneity, and related to outdoor air pollution. However, non-linear association between pollution China remains unclear. Methods In this study, relationships of males females from 207 counties 2013 with annual concentrations PM2.5, PM10, SO 2 , NO CO O 3 were analysed. GeoDetector q statistic was used for examining cancer. Results An apparent...
Abstract Background and Aims Physical activity has proven effective in preventing atherosclerotic cardiovascular disease, but its role degenerative valvular heart disease (VHD) remains uncertain. This study aimed to explore the dose–response association between moderate vigorous physical (MVPA) volume risk of VHD among middle-aged adults. Methods A full week accelerometer-derived MVPA data from 87 248 UK Biobank participants (median age 63.3, female: 56.9%) 2013 2015 were used for primary...
Abstract Aims The cardiovascular-kidney-metabolic (CKM) health approach emphasizes the importance of multidisciplinary early-stage disease prevention. This study aimed to explore sex differences in CKM risk factors associated with common degenerative valvular heart (VHD). Methods A total 436,184 participants (54.4% women; mean age, 58 years) free VHD or failure at baseline and complete information about were included from UK Biobank cohort. We assessed hazard ratios (HRs)...
To evaluate the effect of Life's Essential 8 (LE8), a comprehensive cardiovascular health (CVH) metric from American Heart Association, on risk cardiac conduction disorders (CCD). We conducted prospective cohort study 112,160 adults UK Biobank, free disease at baseline, to examine association between LE8 scores and CCD. were categorized into low (0-49), moderate (50-79), high (80-100) CVH groups. Cox proportional hazards models used estimate hazard ratios (HRs) 95% confidence intervals (CIs)...
Abstract Background The prognostic value of triglyceride-glucose (TyG) index is not yet known for older diabetic patients received right ventricular pacing (RVP). We aimed to investigate the association between TyG and risk heart failure hospitalization (HFH) in RVP. Methods This study was conducted January 2017 2018 at Fuwai Hospital, Beijing, China, included (age ≥ 65 years) that RVP first time. were obtained before implantation. primary endpoint HFH. Results A total 231 divided into three...
Current guidelines lack clear recommendations between the implantation of cardiac resynchronization therapy (CRT) with defibrillator (CRT-D) and CRT pacemaker (CRT-P). We hypothesized that modified model for end-stage liver disease score including albumin (MELD-Albumin score), could be used to select patients who may not benefit from CRT-D. consecutively included CRT-P or CRT-D 2010 2022. The primary endpoint was composite all-cause mortality worsening heart failure. performed...
The relationship between physical frailty, age-related conditions, and the incidence of degenerative valvular heart disease (VHD) remains unclear. This study aimed to investigate potential association frailty development VHD.
Background: Left ventricular ejection fraction (LVEF) remains the basic reference for prevention of sudden cardiac death (SCD) patients, while right (RV) abnormalities have now been associated with SCD risk. A modified benefit assessment tool incorporating RV function parameters in consideration implantable cardioverter defibrillators (ICD) insertion should be taken into account. Methods: We enrolled 954 chronic heart failure (CHF) patients (age 58.8 ± 13.1 years; 79.0% male) quantitative...
Background The relationship between physical frailty, an age-related condition, and the incidence of degenerative valvular heart disease (VHD) remains uncertain. This study aims to investigate potential association frailty development VHD in middle-aged adults from UK Biobank.Methods Biobank participants, initially free failure, were categorized into three groups based on phenotype, including no-frailty, pre-frailty, frailty. Frailty phenotype was determined by evaluating five components:...
ally stenosed "vessel" (where FFRapp=1-FFR).A linear regression model was developed to predict the significance of an isolated stenosis (FFRpred) using first 26 vessels and validated in next 10 vessels.Results: FFR serially diseased 0.75±0.24.FFRapp underestimated FFRtrue 25/34 cases, (discrepancy 0.06±0.014,see figure A) regardless whether interest proximal or distal confounding (p=0.22).The discrepancy true apparent proportional overall severity disease with no significant difference it...
Results: 5639 features were extracted from the images.344 showed a moderate to good correlation in univariate analysis (FDR q-value<0.05,0.6≤AUC≤1) with presence of LGE.The models trained radiomic (GLM: 0.91, RF: 0.94, SVM: 0.90), significantly higher performance than model clinical (AUC: 0.78) temporal validation.External validation AUC 0.70, 0.68 and 0.73 for respectively GLM, RF linear SVM CMR on different scanner. Conclusion:This study demonstrates potential computer-aided diagnosis...