A5012221296- Antibiotics Pharmacokinetics and Efficacy
- Metabolism and Genetic Disorders
- Alcoholism and Thiamine Deficiency
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Epilepsy research and treatment
- Antibiotic Resistance in Bacteria
- Neurological and metabolic disorders
- Biochemical Acid Research Studies
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Neonatal Health and Biochemistry
- Cancer, Hypoxia, and Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Pharmacovigilance and Adverse Drug Reactions
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Neonatal and fetal brain pathology
- Streptococcal Infections and Treatments
- Sexual Differentiation and Disorders
St George's, University of London
2013-2025
St George’s University Hospitals NHS Foundation Trust
2018-2025
City St George's, University of London
2025
University of London
2024
St George's Hospital
2020
National Health Service
2020
Royal Brisbane and Women's Hospital
2019
Institute of Infection and Immunity
2018
Cleveland Clinic
1971-2016
Guy's Hospital
2009
Aims Prescribing is a complex skill required of doctors and, increasingly, other healthcare professionals. Use personal formulary can help to develop this skill. In 2006–9, we developed core list the 100 most commonly prescribed drugs. Our aim in present study was update ‘starter formulary’ ensure its continued relevance for prescriber training. Methods We analysed large contemporary primary and secondary care datasets identify frequently medicinal products. Items were classified into...
This report illustrates the difficulty in managing CNS infection neurosurgical patients, altered drug pharmacokinetics associated with critical illness, and role that therapeutic monitoring (TDM) of CSF can play assisting clinical decision making. The authors present a case external ventricular drain-related ventriculitis critically ill patient who initially presented subarachnoid hemorrhage. They discuss physiological changes found such particular augmented renal clearance (demonstrated...
Abstract Background Pharmacokinetic models contribute to calculating resistance suppression breakpoints and optimizing antibiotic doses. Antibiotic administration details, blood concentrations sample times, infection patient characteristics are required. Inputted data is assumed errorless. Vancomycin a glycopeptide administered by intermittent or continuous infusion. The vancomycin pharmacokinetic/pharmacodynamic profile combines the 24 h AUC MIC ratio (AUC0–24:MIC). AUC0–24:MIC breakpoint...
Clarithromycin is a commonly used macrolide antibiotic. Infection major source of mortality and morbidity in critical care units. Pharmacokinetics may vary during illness suboptimal pharmacokinetic exposure antimicrobials has been shown to be associated with treatment failure. The pharmacokinetics intravenous clarithromycin not previously described. Pharmacokinetic, clinical demographic data was collected from critically unwell adults receiving clarithromycin. Drug concentrations were...
Background: Clarithromycin is a commonly used macrolide antibiotic. Infection major source of mortality and morbidity in critical care units. Pharmacokinetics may vary during illness suboptimal antimicrobial exposure has been shown to be associated with treatment failure. The pharmacokinetics intravenous clarithromycin have not previously described. Methods: Pharmacokinetic, clinical demographic data were collected from critically ill adults receiving clarithromycin. Drug concentrations...
The pharmacokinetics of β-lactam antibiotics in critical illness remain poorly characterized, particularly neonates, children and the elderly. We undertook a pharmacokinetic study commonly used critically ill patients all ages. aims were to produce whole-life model describe extent which standard doses achieve pharmacokinetic/pharmacodynamic targets associated with clinical cure.A total 212 participants an age range from 1 day (gestational 24 weeks) 90 years recruited UK hospital, providing...
Abstract Background Pharmacokinetic (PK) data underlying paediatric penicillin dosing remain limited, especially in critical care. Objectives The primary objective of the Neonatal and Paediatric Pharmacokinetics Antimicrobials study (NAPPA) was to characterize PK profiles commonly used penicillins using obtained during routine care, further understanding variability inform future evidence-based dosing. Methods NAPPA a multicentre amoxicillin, co-amoxiclav, benzylpenicillin, flucloxacillin...
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation drug exposure. Real‐world psoriasis data were used develop a pharmacokinetic/pharmacodynamic (PK/PD) model the first‐line therapeutic antibody ustekinumab. The impact of differing dosing strategies on was explored. Data collected from UK prospective multicenter observational cohort (491 patients ustekinumab monotherapy, levels, and anti‐drug measurements 797 serum samples,...