A5007612395- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- Autophagy in Disease and Therapy
- Vitamin C and Antioxidants Research
- Photosynthetic Processes and Mechanisms
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism, Diabetes, and Cancer
- Connective tissue disorders research
- Hormonal Regulation and Hypertension
- Amino Acid Enzymes and Metabolism
- Tea Polyphenols and Effects
- Free Radicals and Antioxidants
- Aldose Reductase and Taurine
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Caveolin-1 and cellular processes
- Apelin-related biomedical research
- Alcoholism and Thiamine Deficiency
- Dermatological and Skeletal Disorders
- Antioxidant Activity and Oxidative Stress
- Cellular transport and secretion
- Glycogen Storage Diseases and Myoclonus
- Connexins and lens biology
Semmelweis University
2011-2024
Vita-Salute San Raffaele University
2010
Hungarian Academy of Sciences
2005-2008
Eötvös Loránd University
2007
The endoplasmic reticulum (ER) is involved in many functions, including protein folding, redox homeostasis, and Ca(2+) storage signaling. To perform these multiple tasks, the ER composed of distinct, specialized subregions, amongst which mitochondrial-associated membranes (MAM) emerge as key signaling hubs. How functions are integrated with one another living cells remains unclear.Here we show that Ero1α, a controller oxidative folding enriched MAM regulates fluxes. Downregulation Ero1α by...
The redox state of the intraluminal pyridine nucleotide pool was investigated in rat liver microsomal vesicles. vesicles showed cortisone reductase activity absence added reductants, which dependent on integrity membrane. could be oxidized by addition or metyrapone but not glutathione. On other hand, nucleotides were slightly reduced cortisol glucose 6-phosphate, although glutathione completely ineffective. Redox protein thiols/disulfides altered either manipulations affecting NAD(P)+...
Accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to activation three branches (Protein kinase (RNA)-like [PERK], Inositol requiring protein 1 [IRE-1] and Activating trascription factor 6 [ATF6], respectively) unfolded response (UPR). The primary role UPR is try drive back system former or a new homeostatic state by self-eating dependent autophagy, while excessive level ER stress results apoptotic cell death. Our study focuses on PERK- IRE-1-induced arms...
Loss‐of‐function mutations in the gene encoding GLUT10 are responsible for arterial tortuosity syndrome (ATS), a rare connective tissue disorder. In this study GLUT10‐mediated dehydroascorbic acid (DAA) transport was investigated, supposing its involvement pathomechanism. protein produced by vitro translation and incorporated into liposomes efficiently transported DAA. Silencing of decreased DAA immortalized human fibroblasts whose plasma membrane selectively permeabilized. Similarly,...
Aims: Oxidative protein folding in the luminal compartment of endoplasmic reticulum (ER) is thought to be accompanied by generation H2O2, as side-product disulfide bond formation. We aimed examine role H2O2 produced lumen, which on one hand can lead redox imbalance and hence contribute ER stress caused overproduction secretory proteins; other hand, an excellent electron acceptor, might serve additional pro-oxidant physiological oxidative folding. Results: Stimulation production hepatic...
Effect of 5–100 μM epigallocatechin gallate (EGCG) on hepatic glucose 6‐phosphatase (G6Pase) system was investigated. EGCG inhibited G6Pase in intact but not permeabilized rat liver microsomes, suggesting the interference with transport. However, did hinder microsomal 6‐phosphate (G6P) uptake. Instead, it increased accumulation radioactivity after addition [ 14 C]G6P, presumably due to a slower release C]glucose, product luminal hydrolysis. Indeed, found inhibit efflux. Since activity is...
Significance: Cardiovascular disorders are the most important cause of morbidity and mortality in Western world. Monogenic developmental heart vessels highly valuable to study physiological pathological processes cardiovascular system homeostasis. The arterial tortuosity syndrome (ATS) is a rare, autosomal recessive connective tissue disorder showing lengthening, tortuosity, stenosis large arteries, with propensity for aneurysm formation. In histopathology, it associates fragmentation...