A5101418958- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Cholinesterase and Neurodegenerative Diseases
- Digital Games and Media
- Dementia and Cognitive Impairment Research
- Tissue Engineering and Regenerative Medicine
- Biological Research and Disease Studies
- Labor market dynamics and wage inequality
- Cinema and Media Studies
- COVID-19 Pandemic Impacts
- Chemistry Education and Research
- T-cell and B-cell Immunology
- Retinoids in leukemia and cellular processes
- Metabolomics and Mass Spectrometry Studies
- Enzyme Production and Characterization
- Craniofacial Disorders and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Neonatal Respiratory Health Research
- Economic and Technological Innovation
- Media, Gender, and Advertising
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Education Pedagogy and Practices
- Nutritional Studies and Diet
University of Aveiro
2014-2022
Two histopathological hallmarks of Alzheimer's disease (AD), the tau rich neurofibrillary tangles and senile plaques, predominating in amyloid-β (Aβ), have fueled research distinct directions. Evidence suggests that Aβ triggers imbalanced acti
Abstract The amyloidogenic peptide, Aβ, provokes a series of events affecting distinct cellular pathways regulated by protein phosphorylation. Aβ inhibits phosphatases in dose-dependent manner, thus it is expected that the phosphorylation state specific proteins would be altered response to Aβ. In fact several Alzheimer’s disease related proteins, such as APP and TAU, exhibit pathology associated hyperphosphorylated states. A systems biology approach was adopted phosphoproteome, primary...
<b><i>Background/Aims:</i></b> Diagnosing dementia is challenging in many primary care settings, given the limited human resources and lack of current diagnostic tools. With this mind, a care-based cohort was established Aveiro district Portugal. <b><i>Methods:</i></b> A total 568 participants were evaluated using cognitive tests APOE genotyping. <b><i>Results:</i></b> The findings revealed prevalence 12%. strong...
Chronic inflammation is a feature of Alzheimer´s disease (AD), resulting in excessive production inflammatory mediators that can lead to neuroinflammation, contributing alterations Aβ and deposition as Senile Plaques (SPs), neurofibrillary tangles (NFTs) formation, due hyperphosphorylated Tau protein.This work addressed the impact interleukin-8 (IL-8) monocyte chemoattractant protein-1 (MCP-1), two chemokines, on phosphorylation; also evaluated chemokines' levels plasma using samples from...
Neuroproteomics is an evolving field of postgenomic medicine, highlighting the convergence psychiatry/neurology and proteomics, yet compared with neurogenetics, it has received little attention. This study in rat primary neuronal cultures provides example a neuroproteomic approach relevant to psychiatric disease pathophysiology, focusing on Alzheimer's disease. In this context, okadaic acid (OA) routinely used experimental designs investigate phosphorylation-mediated events. It potent...
Retention of intracellular secreted APP (isAPP) can be provoked by the neurotoxic peptide Aβ. The latter decreases in cerebrospinal fluid Alzheimer's disease (AD) patients, as a consequence its cerebral accumulation and deposition into senile plaques. Of similar relevance, (sAPP) levels associated with AD. studies here presented, reinforce link between sAPP Aβ address putative therapeutic strategies. Laminin gelsolin are potential candidates; both prevent fibril formation complexing Aβ, thus...
Journal Article The effect of Aβ and PKC on actin network remodelling Get access A G Henriques, Henriques Laboratório de Neurociências, Centro Biologia Celular, Secção Autónoma Ciências da Saúde, Universidade Aveiro, Campus Santiago, 3810-193 Portugal Search for other works by this author on: Oxford Academic Google Scholar L P Carvalho, Carvalho J M Oliveira, Oliveira O B Cruz e Silva Microscopy Microanalysis, Volume 21, Issue S6, 1 August 2015, Pages 34–35,...
Introducao A prevalencia de deformacoes cranianas posi- cionais aumentou nas ultimas duas decadas, em parte resultante da recomendacao para deitar os recem-nascidos decubito dorsal, modo a prevenir sindrome morte subita. As de- formacoes mais frequentemente encontradas sao pla- giocefalia e braquicefalia, podendo resultar forcas restritivas intra-uterinas ou externas aplicadas no crânio maleavel crianca periodo pos-natal.Objetivo: O objetivo deste trabalho foi realcar, atraves caso clinico,...