Convenient silylborane precursors for introducing N,B-bidentate boryl ligands onto transition metals were designed, prepared, and employed in ready formation of irdium(III) complexes via Si-B oxidative addition. A practical, efficient catalytic ortho-borylation reaction arenes with a broad range directing groups was developed using an situ generated catalyst from the preligand 3c [IrCl(COD)]2.

A general and efficient palladium-catalyzed intermolecular direct C3 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is complete regio- stereoselectivity. All products are E-isomers at C3-position, no Z-isomers or 2-substituted product can be detected.

Drug resistance caused by epidermal growth factor receptor (EGFR) mutation has largely limited the clinical use of EGFR tyrosine kinase inhibitors (EGFR-TKIs) for treatment non-small-cell lung cancer (NSCLC). Herein, to overcome intractable problem drug resistance, proteolysis targeting chimeras (PROTACs) mutants were developed optimizing covalent ligands. Covalent or reversible pyrimidine- purine-containing PROTACs designed, synthesized, and evaluated. As a consequence, PROTAC CP17, with...

Chemoimmunotherapy has shown great potential to activate an immune response, but the immunosuppressive microenvironment associated with T cell exhaustion remains a challenge in cancer therapy. The proper immune-modulatory strategy provoke robust response is simultaneously regulate T-cell and infiltration. Here, new kind of carrier-free nanoparticle developed deliver chemotherapeutic drug (doxorubicin, DOX), cytolytic peptide (melittin, MPI), anti-TOX small interfering RNA (thymocyte...

A new chemistry of hydrazines that is a copper-catalyzed radical reaction to synthesize vinyl sulfones from readily available N-tosylhydrazones has been described. The protocol provides novel strategy for the synthesis various including α, β-disubstituted ones and terminal ones. advantages transformation include excellent E stereoselectivity, broad substrate scope, low cost reagents, convenient operation. efficient one-pot alkynes achieved. studies provide important complementary approaches...

A general and efficient palladium-catalyzed intermolecular direct C–H homocoupling of furans thiophenes has been developed. The reaction is characterized by using molecular oxygen as the sole oxidant complete C5-position regioselectivity. Both C2- C3-substituted or are appropriate substrates. approach provides a straightforward, facile, economical route to bifurans bithiophenes under mild conditions.

An efficient [4+1C]insert approach to the coupling of enaminones with donor/acceptor or donor/donor carbenes by AgOTf-catalyzed C–C bond carbenoid formal insertion/cyclization/[1,5]-shift cascade reaction was successfully developed, providing distinct chemo- and regioselective multisubstituted pyrroles. The plausible mechanism involves two catalytic cycles: in first one, silver ions regioselectively catalyze insertion reaction; second control cyclization [1,5]-shift reactions. This method...

Abstract Nano‐based immunotherapy of therapeutic biomolecules is attractive but tremendously hampered by the poor delivery efficiency. This study reports a novel system fluorinated‐coordinative‐epigallocatechin gallate (EGCG), referring as FEGCG/Zn, through integration fluorination and zinc ions (Zn 2+ ) into EGCG. The robust therapeutics FEGCG/Zn are measured in terms regulating effect on programmed cell death ligand 1 (PD‐L1), effective diverse biomolecules, hitchhiking ability using...

Current neoantigen cancer vaccines activate T cell immunity through dendritic cell/macrophage-mediated antigen presentation. It is unclear whether incorporating B cell-mediated presentation into current could enhance CD4/CD8 to improve their anticancer efficacy. We developed SARS-CoV-2 epitope-guided peptide/mRNA nanovaccines (BSARSTNeoAgVax) efficacy by enhancing tumor-specific antitumor BSARSTNeoAgVax cross-linked with receptor, promoted CD4 cells, increased follicular/nonfollicular and...

An efficient and economical palladium-catalyzed oxidation system has been identified. The system, characterized by not adding ligand using molecular oxygen as the sole oxidant, can realize Tsuji-Wacker of terminal olefins especially styrenes to methyl ketones; in addition, this achieve tandem Wacker oxidation-dehydrogenation α,β-unsaturated ketones.

Silver-catalyzed coupling of two C sp(3)-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as terminal oxidant readily accessible starting materials, displays wide substrate scope broad functional-group tolerance.

Abstract A general and efficient palladium‐catalyzed intermolecular direct C‐2 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is complete regio‐ stereoselectivity. All products are E ‐isomers at C‐2‐position with no Z 3‐substituted were detected. magnified image

Abstract Aqueous ammonium ion batteries (AAIBs) have garnered significant attention due to their unique energy storage mechanism. However, progress is hindered by the relatively low capacities of NH 4 + host materials. Herein, study proposes an electrodeposited tungsten oxide@polyaniline (WO x @PANI) composite electrode as a host, which achieves ultrahigh capacity 280.3 mAh g −1 at 1 A , surpassing vast majority previously reported The synergistic interaction coordination chemistry and...

In this study, a kind of unique Fe2O3/Pt hybrid consisting uniform platinum nanoparticles deposited on nanoflake-shaped Fe2O3 support was prepared by using solvothermal reaction followed heat-induced reduction process. The sample displays well-defined nanoflake-like morphology; remarkably, there are many specific cavities its surface. addition, Pt with narrow size distribution were onto the surface preformed flake-like to form via facile reaction. Thus, can serve as heterogeneous catalyst...

BF3·OEt2-mediated cross-coupling of (SnMe3)2 with aryl triazene offers a new strategy for the synthesis stannane. A variety synthetically useful trimethylstannanes were produced in moderate to good yields this metal-free approach. One-pot sequential Stille different bromides provides short entry both symmetrical and unsymmetrical biaryl compounds.

<title>Abstract</title> This preclinical study evaluates the pharmacokinetics, tolerability, and anticancer efficacy of QD502, a novel quinazolinone-based compound, in rodent models. Pharmacokinetic assessments were performed male BALB/c mice Sprague-Dawley rats after oral intravenous administration. QD502's stability plasma simulated gastrointestinal fluids, as well its potential to inhibit human cytochrome P450 (CYP450) enzymes, was also assessed. Acute (14-day) chronic (28-day) toxicity...

<title>Abstract</title> <bold>Background</bold> Hepatocellular carcinoma (HCC) is a complex and heterogeneous disease wherein cancer stem cells (CSCs) play pivotal role in driving tumorigenesis, metastasis, resistance to therapy. This study sought map the stemness landscape of HCC identify patients who may benefit from immunotherapy. <bold>Methods</bold> A total 26 cell gene sets were obtained StemChecker database. risk model was constructed based on data TCGA, GEO databases, bioinformatics...