A5028963650- Diet and metabolism studies
- Iron Metabolism and Disorders
- Spaceflight effects on biology
- Quinazolinone synthesis and applications
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Body Composition Measurement Techniques
- Gut microbiota and health
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Pancreatic function and diabetes
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Regulation of Appetite and Obesity
- Trace Elements in Health
- Synthesis and biological activity
- Melanoma and MAPK Pathways
- Dietary Effects on Health
- Genetics and Neurodevelopmental Disorders
- Histone Deacetylase Inhibitors Research
- Heart Rate Variability and Autonomic Control
- Bipolar Disorder and Treatment
- Signaling Pathways in Disease
- Physical Activity and Health
St Vincents Institute of Medical Research
2021-2023
Université Rennes 2
2017-2022
École Normale Supérieure de Rennes
2017-2022
Australian Catholic University
2020-2022
The University of Melbourne
2021
Université de Montpellier
2018-2020
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Université de Rennes
2018-2020
Dynamique Musculaire et Métabolisme
2018-2019
Gut microbiota is involved in the development of several chronic diseases, including diabetes, obesity, and cancer, through its interactions with host organs. It has been suggested that cross talk between gut skeletal muscle plays a role different pathological conditions, such as intestinal inflammation cachexia. However, it remains unclear whether directly influences function. In this work, we studied impact modulation on mice function investigated underlying mechanisms. We determined...
New Findings What is the central question of this study? Although microgravity well known to reduce circulating iron in astronauts, underlying mechanism still unknown. We investigated whether hepcidin, a key hormone regulating metabolism, could be involved deleterious effect. main finding and its importance? show that hindlimb suspension, model microgravity, stimulates production hepcidin liver rats. In agreement with biological role we found decrease an increase spleen content...
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe signaling, has limitations. To identify promising scaffolds as starting points for development high-quality chemical probes, we utilized hinge-binding scaffold hopping strategy design new inhibitors. Starting from potent but promiscuous disubstituted 7-azaindole GSK650934, total 32 compounds, composed single-ring,...
Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, displays functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles widespread associated negative health socio-economic impacts. The study aim was determine effect Dry Immersion (DI), severe hypoactivity model, gut microbiota composition. Stool samples were collected from 14 healthy men before after 5 days DI...
The objective of the present study was to determine effects dry immersion, an innovative ground-based human model simulated microgravity and extreme physical inactivity, on iron homeostasis distribution. Twenty young healthy men were recruited submitted 5 days immersion (DI). Fasting blood samples MRI performed before after DI exposure assess status, as well hematological responses. increased spleen concentrations (SIC), whereas hepatic store (HIC) not affected. Spleen sequestration could be...
Abstract Background Iron excess has been proposed as an essential factor in skeletal muscle wasting. Studies have reported correlations between iron accumulation and atrophy, either through ageing or by using experimental models of secondary overload. However, treatments performed most these studies induced extra‐pathophysiological overload, more representative intoxication poisoning. The main objective this study was to determine the impact closer pathophysiological conditions on structural...
Hereditary aceruloplasminemia (HA), related to mutations in the ceruloplasmin (Cp) gene, leads iron accumulation. Ceruloplasmin ferroxidase activity being considered essential for macrophage release, overload is expected, but it not found hepatic and splenic macrophages humans. Our objective was get a better understanding of mechanisms leading excess HA. A clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (Cas9) knockout Cp gene performed on...
Virtual reality using head-mounted displays (HMD) could provide enhanced physical load during active gaming (AG) compared to traditional displays. We aimed compare the elicited by conventional exercise and AG with an HMD. measured energy expenditure (EE) heart rate (HR) in nine healthy men (age: 27 ± 5 years) performing three testing components a randomised order: walking at 6 km/h (W6), AG, additional constraint (AGW; wrist-worn weights). Although we found that HR was not significantly...
Physical inactivity increases the risk to develop type 2 diabetes, a disease characterized by state of insulin resistance. By promoting inflammatory state, ceramides are especially recognized alter sensitivity in skeletal muscle. The present study was designed analyze, mice, whether muscle contribute physical-inactivity-induced For this purpose, we used wheel lock model induce sudden reduction physical activity, combination with myriocin treatment, an inhibitor de novo ceramide synthesis....
What is the central question of this study? Could skeletal muscle be involved in microgravity-induced iron misdistribution by modulating expression hepcidin, master regulator metabolism? main finding and its importance? We demonstrate, rats, that hepcidin upregulation not a transient adaptation associated with early exposure to microgravity intermittent reloading does limit despite having beneficial effect on soleus wasting.
The serine/threonine protein kinase calcium/calmodulin-dependent 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only handful inhibitors CAMKK2 have been disclosed. Having selective small molecule tool to interrogate this will help demonstrate that inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, chemical probe targets CAMKK2.
<div>CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as starting points for development high-quality chemical probes, we utilized hinge-binding scaffold hopping strategy design new inhibitors. Starting from potent but promiscuous disubstituted 7-azaindole GSK650934 (CAMKK2 IC50 = 3 nM), total...
Physical inactivity increases the risk to develop type 2 diabetes, a disease characterized by state of insulin resistance. By promoting inflammatory state, ceramides are especially recognized alter sensitivity in skeletal muscle. The present study was designed analyze, mice, whether muscle contribute physical inactivity-induced For this purpose, we used wheel lock model induce sudden reduction activity, combination with myriocin treatment, an inhibitor de novo ceramide synthesis. Mice were...