A5026564609- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- scientometrics and bibliometrics research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
- Analytical Methods in Pharmaceuticals
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Meta-analysis and systematic reviews
- Cholinesterase and Neurodegenerative Diseases
- Research Data Management Practices
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Lipid Membrane Structure and Behavior
Royal Society
2016
University of Oxford
1984-1988
Park University
1986-1987
Warneford Hospital
1987
Abstract Although the Journal Impact Factor (JIF) is widely acknowledged to be a poor indicator of quality individual papers, it used routinely evaluate research and researchers. Here, we present simple method for generating citation distributions that underlie JIFs. Application this straightforward protocol reveals full extent skew these variation in citations received by published papers characteristic all scientific journals. there are differences among journals across spectrum JIFs,...
The effects of the acute and chronic administration beta-carboline benzodiazepine receptor ligand, FG 7142 were studied in mice. On (at doses between 10 40 mg kg-1) lowered seizure thresholds to infused pentylenetetrazol (PTZ) but showed an unusual dose-response curve that higher had less effect. duration action was considerably longer than other beta-carbolines, such as ethyl-beta-carboline-3-carboxylate (beta CCE). During repeated administration, which initially proconvulsant subsequently...
Seizure thresholds in mice were determined using the pentetrazol infusion method. Concentration of infusate and rate varied to assess optimal parameters for seizure threshold detection. elevations produced by flurazepam decreases FG 7142. An 1.1 ml min-1 was best detecting both increases threshold. However a concentration 2.5 mg ml-1 gave measurement whereas decreased detected with 10 ml-1.
Drugs acting at benzodiazepine receptors can have two types of pharmacological profile: agonists are anxiolytic, anticonvulsant and sedative, whilst benzo diazepine inverse cause anxiety convulsions. In 1982 we showed that a antagonist, Ro 15-1788, prevented the effects both compound doses without intrinsic activity in tests used. We put forward hypothesis receptor complex could undergo possible conformational changes, resulting increases (benzodiazepine agonists) or decreases inhibitory...
Repeated administration of the β‐carboline benzodiazepine receptor ligand FG 7142 produces sensitization to its effects so that full seizures develop (chemical kindling); initially it is only proconvulsant. The present study investigated alterations in function drugs which act at different sites γ‐aminobutyric acid (GABA) complex, after repeated 7142. In kindled mice decreased anticonvulsant and hypothermic GABA agonist muscimol were observed. progabide reduced. contrast a small increase...
The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling accompanied behavioural changes tests anxiety and aggression. responses rats five were examined after chronic treatment with benzodiazepine inverse agonist FG7142. This caused kindling, so that originally proconvulsant drug full seizures. effect is very long-lasting, our previous work mice had suggested it might be an increase anxiety-related behavior. In present no...
Chronic administration of the benzodiazepine inverse agonist FG 7142 has previously been shown to induce seizure activity in mice. In present study we have investigated effects acute and chronic treatment with mice on levels acetylcholinesterase cortex, hippocampus, midbrain striatum. We also stress form handling (vehicle‐injection) levels. A single dose produced a marked elevation total activities hippocampus when compared vehicle‐injected control levels, but were not different from those...
A small, self-selected discussion group was convened to consider issues surrounding impact factors at the first meeting of Open Scholarship Initiative in Fairfax, Virginia, USA, April 2016, and focused on uses misuses Journal Impact Factor (JIF), with a particular focus research assessment. The group’s report notes that widespread use, or perceived JIF assessment processes lends metric degree influence is not justified basis its validity for those purposes, retards moves open scholarship...
A small, self-selected discussion group was convened to consider issues surrounding impact factors at the first meeting of Open Scholarship Initiative in Fairfax, Virginia, USA, April 2016, and focused on uses misuses Journal Impact Factor (JIF), with a particular focus research assessment. The group’s report notes that widespread use, or perceived JIF assessment processes lends metric degree influence is not justified basis its validity for those purposes, retards moves open scholarship...
Tracking the metrics of a more open publishing world will be key to selling “open” and encouraging broader adoption solutions. Will openness mean lower impact, though (for whatever reason—less visibility, less readability, press, etc.)? Why or why not? Perhaps fundamentally, how useful are impact factors anyway? What they really tracking, what do mean? pros cons our current reliance on these measures? Would faculty satisfied with an alternative system as long it is recognized reflecting...
ganglia 6 Behavior 202 Benzodiazepine(s) 108, 186 -receptor ligand 195 Bioamines 149 Bioavailability Bipolar II 61 Blood-brain barrier 180 Blood levels Brainstem auditory evoked potential 104