A5102784357- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Pleural and Pulmonary Diseases
- Organ Transplantation Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Enhanced Recovery After Surgery
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Radiomics and Machine Learning in Medical Imaging
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Cardiac Arrest and Resuscitation
- Ion channel regulation and function
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
Shanghai East Hospital
2011-2025
Tongji University
2013-2021
Nucleotide excision repair (NER) pathway plays critical roles in repairing DNA disorders caused by platinum. To comprehensively understand the association between variants of NER and clinical outcomes platinum-based chemotherapy, 173 SNPs 27 genes were selected to evaluate with toxicities efficiency 1004 patients advanced non-small cell lung cancer. The results showed that consecutive significant signals observed XPA, RPA1, POLD1, POLD3. Further subgroup analysis GTF2H4 presented benefit...
ABSTRACT AZ505, a highly selective inhibitor of SMYD2, exhibits an antifibrotic effect in renal fibrosis. Its on peritoneal fibrosis remains unexplored. In this study, we investigated its effects the development induced by chlorhexidine gluconate (CG) murine model. We found that SMYD2 and trimethylated histone substrate H3K36 (H3K36me3) were expressed tissue following CG injection, administration AZ505 remarkably inhibited their expression, along with attenuating CG–induced expression...
G-protein receptor kinase 5 (GRK5) Gln41 > Leu and β1-adrenergic (ADRB1) Arg389 Gly polymorphisms presented the different distribution of genotype frequencies between Caucasian American African American, produced difference in β-blocker treatment effect among them with systolic heart failure (SHF). This study sought to identify distributed characteristics these variant genotypes Chinese population, influence GRK5 ADRB1 on SHF morbidity patients SHF. was based cross-sectional survey data....
To investigate the clinical application of fast track surgery (FTS) model based on preoperative nutritional risk screening (NRS) in patients with esophageal cancer.180 cancer who underwent between January 2008 and April 2014 were randomly divided into study control groups matched-pairs. The group assessment using NRS 2002 received treatment before was treated by conventional method. Postoperative indicators including time to first exsufflation, defecation, chest tube removal, hospitalization...
Lung adenocarcinoma (LUAD), a major and fatal subtype of lung cancer, caused lots mortalities showed different outcomes in prognosis. This study was to assess key genes develop prognostic signature for the patient therapy with LUAD. RNA expression profile clinical data from 522 LUAD patients were accessed downloaded Cancer Genome Atlas (TCGA) database. Differentially expressed (DEGs) extracted analyzed between normal tissues samples. Then, 14-DEG developed identified survival prediction by...
Abstract Objective The aim of this study was to assess the efficacy and safety intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE) compared normothermic chemoperfusion cavity (NCPC), investigate better treatment control MPE. Methods Malignant patients were enrolled treated NCPC or IPHC under video‐assisted thoracoscopic surgery (VATS). chest drainage duration, clinical characteristics, recurrence time collected for statistical analysis....
Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor subtype accounting for around 0.9% of lung cancers. At present, research on LELC mainly focuses pathological diagnosis, while the molecular mutation landscape still unclear.A 72-year-old female presented productive cough three weeks followed by severe symptoms another week. Respiratory sounds were weak and coarser in right field. F-FDG PET-CTA showed hypermetabolic mass upper lobe as well enlargement hilar subcarinal...
Myocardial ischemia/reperfusion (MIR) injury easily occurrs during cardiopulmonary bypass surgery in elderly patients. In an attempt to develop effective strategy, we employed a pig model of MIR investigate the maximum rate change left ventricular pressure, enddiastolic and intraventricular pressure. Coronary sinus cardiac troponin T (TnT) adenosine-triphosphate (ATP) content myocardium were measured. The ultrastructures for visualized by transmission electron microscopy (TEM). role...
Objective To evaluate the influence of fast-track surgery in perioperative period on clinical outcomes patients at nutritional risk respectable esophageal cancer perioperatively.Methods A total 170 carcinoma receiving radical operation our hospital from January 2008 to December 2013 were randomly divided into two groups by simple random method (n =85 each):one group was treated with new concept FTS-based screening (FTS group),and other control received conventional management (CPM group).The...
Objective In a prospective randomized controlled pilot study, effects of postoperative pulmonary complications on conservative treatment surgery (CTS) and fast track (FTS) regimen in non-small cell lung cancer (NSCLC) patients undergoing lobectomy were compared.Methods Eighty who underwent radical surgical for disease from January 2008 to May 2010 our hospital random assigned either (40 FTS group) or CTS group). Study endpoints ( pneumonia, atelectasis, prolonged air leak ＞ 7 days); Further...
Objective To study the effects of improving elderly patients with bowel dysfunction after cardiopulmonary bypass.Methods Choose 54 CPB were randomly divided into tree groups:the control group and Gln Combination group,every has 18 patients.Glutamine(Gln) at 0.4 g/kg was administrated to in combination during beginning two days operation.Based on group,the The given different oral Chinese medicine before operation,according syndrome differentiation classification.Plasma endotoxin,IL-6 DAO...
Objective By establishing the swine cardiopulmonary bypass(CPB) myocardial ischemia-reperfusion (MI/R) mod-el, early phase cardioprotective effects and role of mitochondrial KATP channel were studied to provide basic experimen-tal evidences for clinical card-ioprotection. Methods 24 adult swines(30-35 kg) randomly divided into 3 groups:group C(con-trol group, n=8), group D(using δ-opiold agonist-DADLE,n = 8) D+ K (using DADLE Glibenclamide, n=8).CPB was instituted routinely improved St....
Objective By establishing the swine cardiopulmonary bypass(CPB) myocardial ischemia-reperfusion(MI/R) model, early phase and late cardioprotective effects of δ-opioid receptor agonist DADDLE were studied to provide academic experimental evidences for clinical cardioprotection. Methods 24 adult swines randomly divided into 3 groups: control group(n=8), cardioprotection group(n=8) group(n= 8). CPB was instituted routinely modified St. Thomas cold cardioplegic solution administered root aorta....
Lung adenocarcinoma is one of the common causes cancer-related deaths worldwide. Histone cluster 1 H2A family member b (HIST1H2AB) a histone family. Bioinformatic analyses have revealed that HIST1H2AB highly expressed in some cancers and might be an oncogene. However, information on function lung limited.The expression was analyzed normal lung, paracancerous tissues from The Cancer Genome Atlas (TCGA) database immunohistochemistry staining. It further verified relative cell lines using...