A5101840694- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Urinary Bladder and Prostate Research
- Medicinal Plants and Bioactive Compounds
- Forensic Toxicology and Drug Analysis
- Extracellular vesicles in disease
- Hormonal and reproductive studies
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Muscle metabolism and nutrition
- Spinal Cord Injury Research
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Alcohol Consumption and Health Effects
University of Suwon
2016-2020
The antihyperglycemic effect of a water extract (WE) and an alkali (AE) the Fomitopsis pinicola fruit body was studied in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetes mellitus (DM) control group lost significant amount weight, whereas normal (NC) gained weight; however, DM-AE with weight gain approaching normal. Feed intake by also similar to NC group. liver kidney weights per increased STZ treatment; were lower F. pinicola-treated groups nearly normalized heart, lungs,...
We analyzed autophagy/mitophagy flux in vitro (C2C12 myotubes) and vivo (mouse skeletal muscle) following the treatments of autophagy inducers (starvation, rapamycin) a mitophagy inducer (carbonyl cyanide m-chlorophenylhydrazone, CCCP) using two immunodetection methods, ELISA Western blotting, compared their working range, accuracy, reliability. The ELISAs showed broader range than that LC3 blots (Table 1). Table 2 data value distribution was tighter average standard error from much smaller...
The protective effects of freeze-dried privet (Ligustrum obtusifolium) fruits (PFs) were observed in streptozotocin (STZ)-induced diabetic rats on a high fat diet by measuring levels blood glucose, serum insulin, fructosamine, and hepatic reactive oxygen species generating scavenging enzyme activities. A PF-supplemented was prepared mixing an AIN-76 with powdered PF (final concentration, 1% or 2%). It fed to STZ-induced for 6 weeks. Diabetic animals receiving the showed significant increase...
Recent studies have suggested a novel therapeutic strategy for treatment of benign prostatic hyperplasia (BPH) via modulation autophagy. However, it is not clear whether autophagy induction or inhibition can render better efficacy BPH because activation in tissue precisely known and still contradictory. The purpose this study was to examine the levels cells.We analyzed compared autophagic flux which defined as measure degradation activity two human prostate epithelial cell lines, RWPE-1...
PURPOSE: The aims of this study were to investigate if autophagy was up-regulated in skeletal muscle from old mice, and determine endurance exercise training can intervene the process mouse tissue. METHODS: Two age groups (10-week 18-month old) mice assigned either swimming or sedentary control group. Male wild-type ICR performed five daily bouts one hour per week for 8 weeks. To autophagic flux muscle, treated with without 2 days 0.4 mg/kg/day colchicine (blocking degradation autophagosome)...
PURPOSE Finasteride is a competitive inhibitor of 5-alpha reductase type 2 enzyme that commonly used to treat benign prostatic hyperplasia and male pattern hair loss. It not clear about the synergistic effects finasteride resistance training on protein homeostasis in androgen-target tissue such as skeletal muscle. Thus, purpose this study was investigate 8-week exercise synthesis autophagic degradation rat METHODS Forty-eight wild-type Sprague Dawley rats (8weeks old) were randomly assigned...
PURPOSE Benign prostatic hyperplasia (BPH) is a typical male adult disease in which the prostate enlarged but not cancerous. Autophagy catabolic process of cellular constituents and mechanism for homeostasis tissues. Currently, it established whether BPH linked to autophagy or endurance exercise training, an activator, can ameliorate its symptoms. Therefore, purpose this study was investigate closely related with dysregulation induced by training relieve BPH. METHODS Forty-eight wild-type SD...