A5068785157- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Liver Disease and Transplantation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Colorectal Cancer Treatments and Studies
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
Yokohama City University
2025
Gunma Chuo Hospital
2016-2024
Kurashiki Central Hospital
2021
John Wiley & Sons (United States)
2016
Japanese Foundation For Cancer Research
2009-2015
Curative treatment options for patients with early stage hepatocellular carcinoma (HCC) include resection, liver transplantation, and percutaneous ablation therapy. However, even solitary HCC are not always amenable to these treatments. The authors prospectively investigated the clinical outcomes of who received stereotactic body radiotherapy (SBRT) HCC.A phase 2 study involving SBRT optional transarterial chemoembolization (TACE) was conducted in Child-Pugh grade A or B underlying,...
Potentially curative treatments for early‐stage hepatocellular carcinoma (HCC) have drawbacks and contraindications. Recently, radiotherapy has achieved good outcomes. We compared the outcomes of radiofrequency ablation (RFA) HCC. Consecutive patients with ≤3 HCC lesions tumor diameters cm treated RFA or were reviewed. was first choice unsuitable surgery. Otherwise, stereotactic body in five fractions mainly performed. For adjacent to gastrointestinal tract, mild hypofractionation Propensity...
Abstract Aim To prospectively evaluate the efficacy and safety of stereotactic body radiotherapy (SBRT) for patients with previously untreated solitary primary hepatocellular carcinoma (HCC). Methods The main eligibility criteria included following: (1) HCC; (2) no prior treatment (3) Child–Turcotte–Pugh score seven or less; (4) unsuitability refusal surgery radiofrequency ablation (RFA). prescribed dose SBRT was 40 Gy in five fractions. endpoint 3‐year overall survival (OS); secondary...
We previously reported that the local control of pulmonary metastases from colorectal cancer (CRC) following stereotactic body radiotherapy (SBRT) with moderate prescription dose was relatively worse. investigated treatment outcomes and toxicities patients oligometastases CRC treated by SBRT using risk-adapted, very high- convergent-dose regimens. Among referred for August 2011 to January 2015, those were extracted who had liver or CRC, they a total 50-60 Gy in five fractions prescribed 60%...
Abstract Aim Stereotactic body radiotherapy (SBRT) is an emerging treatment for hepatocellular carcinoma (HCC) and has shown excellent local control (LC), as radiofrequency ablation (RFA). As no randomized controlled trial compared SBRT RFA HCC, data from a propensity score matched study (PSMS) are valuable. However, the results varied greatly depended on composing factors of Barcelona Clinic Liver Cancer staging (BCLC‐factors) adjusted. Therefore, we undertook systematic review...
Abstract Constitutive stimulation of estrogen signaling in mice causes dilated uterine glands with activation epithelial cell proliferation. In receptor β knockout (Esr2KO) mice, proliferation the epithelium is permanently stimulated; therefore, we histologically analyzed structure Esr2KO age. uterus dilation was accelerated and collagen accumulated stroma. The were age even wild-type (WT) mice; however, quantitatively. expression FOXA2 transcription factor, which essential for glandular...
Background: To clarify local control by salvage stereotactic body radiotherapy (SBRT) for recurrent/residual hepatocellular carcinoma (HCC) compared with initial definitive SBRT treatment-naïve HCC.Material and methods: We retrospectively investigated HCC patients that received between July 2005 December 2017. classified tumors as the group (Arm-1; SBRT, Arm-2; planned following transarterial chemoembolization (TACE)) (Arm-3; after TACE, Arm-4; radiofrequency ablation (RFA), Arm-5; other...
Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and used to treat respiratory inflammatory diseases. has similar pathology them. Adverse reactions macrolides few self-limited. We thus administered CAM patients with high-risk factors for radiation pneumonitis, retrospectively investigated whether mitigated following stereotactic body radiotherapy...
We retrospectively investigated outcomes, including pulmonary toxicities, of stereotactic body radiation therapy using RapidArc and a risk-adapted 60% isodose plan for early-stage non-small-cell lung cancer patients. evaluated patients staged as cT1a-2bN0M0 between 2011 2017 treated with total dose 40-60 Gy in five fractions to the line maximum encompassing planning target volume curative intent. Comorbidities age were rated an age-adjusted Charlson comorbidity index (AACCI). Factors...
Abstract Aim Decisions regarding therapeutic plans for inoperable patients with hepatocellular carcinoma (HCC) adjacent to the gastrointestinal (GI) tract are challenging because radiofrequency ablation has potential risk of thermal injury. Moreover, response rate transcatheter arterial chemoembolization is relatively low and stereotactic body radiotherapy (SBRT) believed be too toxic. We have applied hypofractionated (HFRT) such lesions. This study investigated outcomes toxicities this...
Radiotherapy is one of the available curative therapies for hepatocellular carcinoma (HCC). We investigate use contrast-enhanced ultrasound using Sonazoid (SCEUS) in evaluating efficacy radiotherapy HCC. enrolled 59 patients with HCCs this retrospective study. Tumor size and tumor vascularity were evaluated SCEUS before 1, 3, 7, 10, 13 months after radiotherapy. The median follow-up period was 44.5 (range: 16–82 months). Of HCCs, 95% (56/59) had no local recurrence, while 5% (3/59) did. At...
The evidence for stereotactic body radiotherapy (SBRT) is meagre patients with clinical T3-4N0M0 non-small cell lung cancer (8th Edition of the Union International Cancer Control (UICC)). This study retrospectively investigated outcomes following SBRT such patients. Among consecutive treated SBRT, staged as cT3-4N0M0 by all criteria were examined, most whom unsuitable to chemoradiotherapy due their fragile characters. Clinical evaluated and factors associated investigated. Between 2005 2017,...
This study sought to develop and validate a prognostic model for non-lung cancer death (NLCD) in elderly patients with non-small cell lung (NSCLC) treated stereotactic body radiotherapy (SBRT). Patients aged ≥65 diagnosed NSCLC (Tis-4N0M0), tumor diameter ≤5 cm SBRT between 1998 2015 were retrospectively registered from two independent institutions. One institution was used development (arm D, 353 patients) the other validation V, 401 patients). To identify risk factors NLCD, multiple...