A5043867015- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Bone Tissue Engineering Materials
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Urological Disorders and Treatments
- Surgical Sutures and Adhesives
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Corneal Surgery and Treatments
- Microencapsulation and Drying Processes
- RNA Interference and Gene Delivery
- Polymer Nanocomposite Synthesis and Irradiation
- Curcumin's Biomedical Applications
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Conducting polymers and applications
- Nanoparticles: synthesis and applications
- Reconstructive Surgery and Microvascular Techniques
- Phytochemistry and biological activity of medicinal plants
Université Laval
2022-2024
Tehran University of Medical Sciences
2016-2020
Cornell University
2020
Case Western Reserve University
2020
Wound healing is known as one of the most complicated biological processes for injured skin caused by surgical, trauma, burns, or diabetic diseases, which causes a nonfunctioning mass fibrotic tissue. Recent reports have suggested that exosomes (EXOs) secreted this type stem cells may contribute to their paracrine effect. In study, EXOs were isolated from supernatant cultured adipose-derived (ADSCs) via ultracentrifugation and filtration. The EXO loaded in alginate-based hydrogel was used...
Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun mat loaded berberine (Beri) as DFU-specific dressing. The healing efficacy of fabricated dressings evaluated streptozotocin-induced rats. results demonstrated an average nanofiber diameter 502 ± 150 nm, tensile strength, contact angle, porosity, water vapor...
The present study aimed to evaluate the efficacy of cellulose acetate/gelatin/nanohydroxyapatite (CA/Gel/nHA) nanocomposite mats as wound dressing. dressings were prepared with electrospinning CA/Gel solutions containing 12.5, 25 and 50 mg nHA. evaluated regarding their water uptake capacity, morphology, tensile strength, vapour transmission rate, wettability cellular response L929 cell line. results showed that concentration nHA had a direct correlation porosity, contact angle, uptake,...
Abstract Combat or burn injuries are associated with a series of risks, such as microbial infection, an elevated level inflammatory response, and pathologic scar tissue formation, which significantly postpone wound healing also lead to impaired repair. Skin engineering for requires biomimetic dressing substrate ideal hydrophilicity, holding antioxidant antimicrobial properties. In addition, available bioactive specification is required reduce stimulate angiogenesis, improve this study, we...
Abstract The current study aimed to enhance the efficacy of peripheral nerve regeneration using an electrically conductive biodegradable porous neural guidance conduit for transplantation allogeneic Schwann cells (SCs). was produced from polylactic acid (PLA), multiwalled carbon nanotubes (MWCNTs), and gelatin nanofibrils (GNFs) coated with recombinant human erythropoietin‐loaded chitosan nanoparticles (rhEpo‐CNPs). PLA/MWCNTs/GNFs/rhEpo‐CNPs had porosity 85.78 ± 0.70%, contact angle 77.65...
Abstract The focus of the current study was to develop a functional and bioactive scaffold through combination 3D polylactic acid (PLA)/polycaprolactone (PCL) with gelatin nanofibers (GNFs) Taurine (Tau) for bone defect regeneration. GNFs were fabricated via electrospinning dispersed in PLA/PCL polymer solution, Tau different concentrations added, solution converted into porous thermally-induced phase separation technique. characterization results showed that scaffolds have interconnected...
In this study, taurine (2-aminoethane sulfonic acid), an amino acid found in large amounts most mammalian tissues, was incorporated with poly (ε-caprolactone) and gelatin order to develop a drug-loaded composite wound dressing material. The mats from (ε-caprolactone)/gelatin (1:1 (w/w)) solution 3%, 5%, 10% (w/w) of were produced by electrospinning. electrospun evaluated regarding their morphology, wettability, water uptake capacity, vapor transmission rate, tensile strength, cellular...
Background and aim: Healing of fire-induced wounds has been still a challenge in clinical issues. The aim this study was to fabricate nanofibrous poly (L-lactic acid)/collagen (PLLA/COL) scaffold with sustained release aloe vera (AV) gel using chitosan (CT)-coated layer for skin tissue engineering applications. Material methods: Morphology, porosity, tensile strength, hydrophilicity, degradation rate, water vapor permeability uptake ratio the were characterized. behaviors mouse fibroblasts...
Abstract The current study aimed to investigate the potential of carbon nanofibers promote peripheral nerve regeneration. nanofiber-imbedded scaffolds were produced from polycaprolactone and using thermally induced phase separation method. Electrospinning technique was utilized fabricate polycaprolactone/collagen nanofibrous sheets. incorporation into polycaprolactone’s matrix significantly reduced its electrical resistance 4.3 × 10 9 ± 0.34 Ω 8.7 4 1.2 Ω. Further in vitro studies showed...
The current study aimed to enhance the efficacy of peripheral nerve regeneration using a hydroxyapatite nanoparticle-containing collagen type I hydrogel. A solution collagen, extracted from rat tails, was incorporated with nanoparticles (with average diameter ~212 nm) and crosslinked 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) prepare Schwann cell cultivation on prepared hydrogel demonstrated significantly higher proliferation than tissue culture plate, as positive control, after 48...
This study aimed to develop a recombinant human erythropoietin/aloe vera gel–releasing polyvinyl alcohol/chitosan wound dressing by wet-electrospinning method and investigate the synergistic effects of erythropoietin aloe gel on excisional healing. The (4:1 (w/w)) solution was electrospun into an gel–containing water coagulation bath then coated with erythropoietin–loaded chitosan nanoparticles prepared via ionic gelation technique. developed sponge-like film able release for at least 7 1...
The current study was conducted to promote the extent of peripheral nerve regeneration using a collagen type I hydrogel containing chitosan nanoparticle loaded by insulin. developed increased proliferation rate Schwann cells as shown tetrazolium salt-based assay. For functional analysis, administrated in sciatic crush injury Wistar rats. results index, hot plate latency, compound muscle action potential amplitude and weight-loss percentage wet gastrocnemius muscle, indicated that prepared...
To evaluate the application of a fabricated dressing containing kaolin for skin regeneration in rat model excisional wounds.In present study, was loaded into electrospun polyvinyl alcohol (PVA)/chitosan polymer blend to develop composite nanofibrous dressing. make yarns, with weight ratio 5% added PVA/chitosan and subsequently formed nanofibres using electrospinning method. Scaffolds were evaluated their microstructure, mechanical properties, surface wettability, water vapour transmission...
In this study, the single and synergistic effects of montmorillonite curcumin-loaded chitosan microparticles incorporated onto polylactic acid films were investigated on full-thickness excisional wounds rats . The microfibrillated film was electrospun from a 10% (w/v) in chloroform solution. prepared via ionic gelation technique with high drug loading encapsulation efficiency. alkaline-treated assembled positively charged as first layer negatively (NC dressing), (CCM their mixture (1:1...
In the current study, tetracycline hydrochloride (TCH), an antibiotic against most of medically relevant bacteria, was incorporated into poly (ε-caprolactone)/poly lactic acid solution in order to develop a composite scaffold with both antibacterial and osteoinductive properties for repair infected bone defects. The scaffolds were produced from (ε-caprolactone) (PCL) (PLA) (1:1 (w/w)) 3, 5, 10% (w/w) TCH by thermally induced phase separation technique. evaluated regarding their morphology,...