A5069552335- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Renal and related cancers
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Pesticide and Herbicide Environmental Studies
- RNA modifications and cancer
- FOXO transcription factor regulation
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Combustion and Detonation Processes
- Pancreatic and Hepatic Oncology Research
- Chromatin Remodeling and Cancer
- Paraquat toxicity studies and treatments
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Hedgehog Signaling Pathway Studies
- Food Safety and Hygiene
Northeast Agricultural University
2025
Shenyang University
2024
Tongji Hospital
2018-2024
Huazhong University of Science and Technology
2018-2024
Huaqiao University
2024
Xi'an University of Science and Technology
2024
Fujian Medical University
2024
Shanghai Municipal Center For Disease Control Prevention
2024
Massachusetts General Hospital
2023
Taiyuan Iron and Steel Group (China)
2023
Abstract The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for Kras LSL−G12D/+ Tp53 fl/fl (KP) and Lkb1 (KL) NSCLC mouse models by recruiting conventional DC 1 (cDC1) into TME promote T expansion. exhibits high expression in tissues is positively correlated with infiltration cDC1 overall survival patients. deficiency impairs subsequent expansion CD8 +...
Despite the FDA approval of mTOR inhibitors (mTORi) for treatment renal cell carcinoma (RCC), benefits are relatively modest and few responders usually develop resistance. We investigated whether resistance to mTORi is due upregulation PD-L1 underlying molecular mechanism.The effects transcription factor EB (TFEB) on RCC proliferation, apoptosis, migration were evaluated. Correlation TFEB with expression, as well inhibition was assessed in human primary clear RCCs. The regulation by...
Abstract Background Early invasion and metastasis are responsible for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC), epithelial-to-mesenchymal transition (EMT) is recognized as a crucial biological progress in driving tumor metastasis. The transcription factor FOXO3a inactivated various types solid cancers loss associated with EMT In this study, we sought to explore whether SPRY2, regulator receptor tyrosine kinase (RTK) signaling, involved FOXO3a-mediated PDAC. Methods...
The mismatch repair (MMR) deficiency of cancer cells drives mutagenesis and offers a useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not respond to immunotherapy, highlighting the need alternative approaches target MMR-d cells. Here, we show that inhibition ATR kinase preferentially kills Mechanistically, inhibitor (ATRi) imposes synthetic lethality on by inducing DNA damage in replication- MUS81 nuclease-dependent manner. induced ATRi is colocalized with...
Small cell lung cancer (SCLC) is a highly malignant and heterogeneous with limited therapeutic options prognosis prediction models. Here, we analyzed formalin-fixed, paraffin-embedded (FFPE) samples of surgical resections by proteomic profiling, stratified SCLC into three subtypes (S-I, S-II, S-III) distinct clinical outcomes chemotherapy responses. The subtyping was an independent prognostic factor performed better than current tumor-node-metastasis or Veterans Administration Lung Study...
Abstract Background Unfavourable lipid and glucose levels may play a crucial role in the pathogenesis of gestational diabetes mellitus (GDM). However, there is lack prospective studies on relationship between profiles, ratios GDM during pregnancy. Aims To prospectively investigate profile early mid-pregnancy their pattern change from to risk GDM. Methods This nested case-control study was based maternal child healthcare hospitals Fujian Province, China. We included pregnant women who...
Abstract Background and Objectives p53 gene has a dual role as trigger of apoptosis an initiator DNA repair. Gadd45a assumes the function to maintain stability genome. The present study was designed assess significance protein expression on pancreatic cancer. Methods immunohistochemically studied in 59 patients with Results positive rate 67.8% 42.4%, respectively. <65 years significantly higher than that ≥65 ( P = 0.030). Gadd 45a showed no correlation patients' age. There relation for...
Aims SOX 11 is known as an essential transcription factor for regulating neurogenesis. Recently, has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma ( MCL ). However, other tumour types not yet extensively studied. Methods results Herein, we examined 2026 cases neuroectodermal, germ cell, mesenchymal epithelial tumours by immunohistochemistry. was consistently expressed all neuroectodermal with neural differentiation, well...
The alternative usage of promoters provides a way to regulate gene expression, has significant influence on the transcriptome, and contributes cellular transformation cancer. However, function (APs) in hepatocellular carcinoma (HCC) not been systematically studied yet. In addition, potential mechanism regulation APs remains unclear. DNA methylation, one most aberrant epigenetic modifications cancers, is known transcriptional activity. Whether methylation regulates needs be explored. Here, we...
The blast crisis (BC) is the final deadly phase of chronic myeloid leukemia (CML), which remains a major challenge in clinical management. However, underlying molecular mechanism driving blastic transformation unclear. Here, we show that ASF1A, an essential activator, enhanced to CML-BC by mediating cell differentiation arrest. ASF1A expression was aberrantly increased bone marrow samples from patients compared with newly diagnosed CML-chronic (CP) patients. inhibited and promoted CML...
To investigate the distribution, contamination status, and antibiotic resistance of Listeria monocytogenes in four types retail poultry meat, including chicken, duck, goose, pigeon, sold Jiading District, Shanghai. A total 236 meat samples were collected, L. isolates obtained for identification susceptibility testing against 14 common antibiotics. Forty-one detected from samples, with detection rates 24.47%, 19.44%, 14.75%, 4.44% pigeon respectively. Among refrigerated, frozen, room...
Hot surfaces in industrial processes and automotive systems present a remarkable fire hazard. Lubricating oil is widely used these scenarios. Quantifying the ignition characteristics flame behavior of lubricating on hot critical for enhancing safety energy-related applications. This paper utilizes self-developed experimental platform surface to systematically conduct combustion tests with varying volumes at different temperatures. Through statistical analysis image processing, temperature,...
Abstract Background Synaptophysin (SYN), chromogranin A (CGA), CD56 and insulinoma-associated protein 1 (INSM1) are proposed neuroendocrine (NE) markers used for diagnosis of pulmonary NE tumors. These have been identified in subsets non-NE tumors requiring differential diagnosis, thus we sought to explore new markers. Methods We evaluated the immunohistochemical expression SOX11, a transcription factor involved neurogenesis, large cell carcinomas (LCCs). Results found that SOX11 showed...
Thioredoxin domain containing 11 (TXNDC11) has been implicated in numerous cancers. Nevertheless, the function of TXNDC11 glioma is not well described. This study aimed to assess clinical significance based on bioinformatics analysis and immunohistochemical (IHC) staining.GEPIA2, The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) databases were employed detect levels transcript glioma. expression profiles data from methylation chip with details TCGA Chinese Glioma (CGGA) samples...
1. Yin S, Ahluwalia IB, Palipudi K, Mbulo L, Arrazola RA. Are there hardened smokers in low- and middle-income countries? Findings from the Global Adult Tobacco Survey. Tob Induc Dis. 2019;17:11. doi:10.18332/tid/100631 CrossRef Google Scholar
Background. Insulinoma-associated protein 1 (INSM1) has been identified as a nuclear marker of neuroendocrine tumors. Although INSM1 appears to be subtle and specific biomarker for tumor, its expression clinicopathological significance in mesenchymal tumors remain unclear. Methods. We analyzed mRNA level GEO database conducted immunohistological staining detect the on 576 from pathology department Tongji Hospital. Results. At transcription level, AITL (angioimmunoblastic T-cell lymphoma) was...
Small cell lung cancer (SCLC) is a malignant and heterogeneous with limited therapeutic options insufficient prognostic models. Here, we analyzed formalin-fixed, paraffin-embedded (FFPE) samples of surgical resections by proteomic profiling, stratified SCLC into three subtypes (S-I, S-II, S-III) distinct clinical outcomes chemotherapy responses. The subtyping was an independent factor performed better than current TNM or VALG staging methods. result could be further validated using FFPE...
Abstract Background. Unfavourable lipid and glucose levels may play a crucial role in the pathogenesis of gestational diabetes mellitus (GDM). However, there is lack prospective studies on relationship between profiles,lipid ratios GDM during pregnancy. Aims To prospectively investigate profile early mid-pregnancy their pattern change from to risk GDM. Methods This nested case-control study was based maternal child healthcare hospitals Fujian Province, China. We included pregnant women who...
Abstract A magnetic and efficient Fe 78 Si 9 B 13 /MnO 2 composite was successfully fabricated by a facile hydrothermal method. This employed as Fenton-like catalyst for the degradation of methyl orange (MO) under activation H O . The phase morphology were characterized X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive spectroscopy. experimental results reveal that theoretical mass loading dosage have significant effect on MO...