A5090472320- Nanoparticle-Based Drug Delivery
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Advanced Drug Delivery Systems
- Cancer, Hypoxia, and Metabolism
- Vitamin D Research Studies
- Radiation Therapy and Dosimetry
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Ferrocene Chemistry and Applications
- Electrospun Nanofibers in Biomedical Applications
- Nitric Oxide and Endothelin Effects
- ATP Synthase and ATPases Research
- Boron Compounds in Chemistry
Université d'Angers
2016-2025
Inserm
2016-2025
Nantes Université
2017-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2019-2025
Centre National de la Recherche Scientifique
2019-2025
Equilibrium Research
2019
Micro et Nanomédecines translationnelles
2008-2016
Zimmer Biomet (France)
2009-2016
Université Nantes Angers Le Mans
1994-2015
Centre Hospitalier Universitaire d'Angers
1996-2011
Stem cells in the embryonic mammalian CNS are initially responsive to fibroblast growth factor 2 (FGF2). They then undergo a developmental programme which they acquire epidermal (EGF) responsiveness, switch from production of neuronal glial precursors and become localized specialized germinal zones such as subventricular zone (SVZ). Here we show that extracellular matrix molecules act regulators this programme. Tenascin C is highly expressed SVZ, transgenic mice lacking tenascin delayed...
The extracellular matrix glycoprotein tenascin-C is widely expressed in the vertebrate central nervous system (CNS) during development and repair. Despite multiple effects of on cell behaviour culture, no structural abnormalities CNS other organs have been found adult tenascin-C-null mice, raising question whether this has a significant role vivo. Using transgenic approach, we demonstrated that regulates both proliferation migration oligodendrocyte precursors development. Knockout mice show...
Astrocytes play a pivotal role in CNS detoxification pathways, where glutathione (GSH) is involved the elimination of oxygen and nitrogen reactive species such as nitric oxide. We have previously demonstrated that specific activity gamma-glutamyl transpeptidase (gamma-GT), an enzyme central significance GSH metabolism, regulated vivo astrocytes by 1,25-dihydroxyvitamin D3 (1,25-D3). The aim present work was to investigate, primary cultures newborn rat astrocytes, effects this hormone on...
By focusing on rat glioma, we elucidated whether new lipid nanocapsules (LNC) were able to improve anticancer hydrophobic drug bioavailability while also overcoming multidrug resistance. Blank LNCs and loaded with the antineoplastic agent paclitaxel formulated by an emulsion inversion phase process. Expression of efflux pumps glioma cells was assessed reverse transcription-PCR, Western blot, immunohistochemistry, their activity followed using tracer (99)Tc(m)-methoxyisobutylisonitrile....
This study, based on in situ hybridization and immunolabeling experiments, presents the time-course cellular distribution of inducible NO synthase (iNOS) expression a rat model brain inflammation. Both intrahippocampal injection lipopolysaccharide (LPS) or buffer (stab lesion) induce an early, transient, restricted iNOS mRNA immunoreactivity CNS. The topographic phenotypic characteristics iNOS-producing cells are distinct. After stab lesion, mRNAs, expressed at 5 h mainly interventricular...
Glioblastoma (GB), the most aggressive brain cancer, remains a critical clinical challenge due to its resistance conventional treatments. Here, we introduce locoregional targeted-α-therapy (TAT) with rat monoclonal antibody 9E7.4 targeting murine syndecan-1 (SDC1) coupled α-emitter radionuclide astatine-211 (
Abstract Analysis of Tenascin‐C (TN‐C) knockout mice revealed novel roles for this extracellular matrix (ECM) protein in regulation the developmental programme oligodendrocyte precursor cells (OPCs), their maturation into myelinating oligodendrocytes and sensitivity to growth factors. A major component ECM developing nervous tissue, TN‐C was expressed zones proliferation, migration morphogenesis. Examination showed control OPC proliferation towards myelination [E. Garcion et al. (2001)...
1,25-dihydroxyvitamin D3 (1,25-D3) is already known to prevent clinical signs of experimental allergic encephalomyelitis when animals are treated during the immunization phase. In present work we have evaluated ability 1,25-Dj inhibit chronic relapsing encephalomylitis (EAE) Lewis rat, administered after beginning signs. We observed a significant improvement in l,25-D3-treated rats. This effect was accompanied by profound inhibition CD4 antigen expression central nervous system (CNS)...
As the pentaspan stem cell marker CD133 was shown to bind cholesterol and localize in plasma membrane protrusions, we investigated a possible function for endocytosis. Using siRNA knockdown strategy non-differentiated human colon cancer Caco-2 cells that constitutively over-expressed CD133, provide first time direct evidence role of intracellular accumulation fluorescently labeled extracellular compounds. Assessed using AC133 monoclonal antibody, improve Alexa488-transferrin (Tf) uptake but...