A5022944316- Tracheal and airway disorders
- Vestibular and auditory disorders
- Antioxidant Activity and Oxidative Stress
- Hearing, Cochlea, Tinnitus, Genetics
- PI3K/AKT/mTOR signaling in cancer
- Olfactory and Sensory Function Studies
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Glaucoma and retinal disorders
- Coconut Research and Applications
- Protein Degradation and Inhibitors
- Hearing Loss and Rehabilitation
- Bioactive natural compounds
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Noise Effects and Management
- Dysphagia Assessment and Management
- Ophthalmology and Eye Disorders
- Ear and Head Tumors
- Advanced Chemical Sensor Technologies
- Meningioma and schwannoma management
Hospital Universitario de Getafe
2017-2025
Universidad Europea
2021-2022
Hospital Universitario La Paz
2021
Clinica Universidad de Navarra
2018
To evaluate the incidence of certain symptoms in a population health workers exposed to coronavirus disease 2019 patients.Case-control study.The study was conducted at tertiary care hospital from March 1 April 7, 2020. Health with suspected (COVID-19) infection were included. The presence COVID-19 detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients used as case control groups, respectively. This analyzed both patient groups. Visual...
During the SARS‐CoV‐2 pandemic, patients in intensive care units who are undergoing long‐term intubation may require tracheostomy. There is controversy about indication and health professionals’ safety regarding conventional or percutaneous technique. We performed a prospective analysis of series 27 consecutive with COVID‐19 comparing both tracheostomy techniques, safety, prognosis clinical markers. The results show that techniques equally safe, without cases infection surgeons. Sequential...
Age-related hearing loss (ARHL) is an increasing and gradual sensorineural dysfunction. Oxidative stress essential factor in developing ARHL; additionally, premature senescence of auditory cells induced by oxidative can produce loss. Hydrogen peroxide (H2O2) represents a method commonly used to generate cellular vitro. The objective the present paper study H2O2-induced patterns three cell lines (House Ear Institute-Organ Corti 1, HEI-OC1; organ Corti, OC-k3, stria vascularis, SV-k1 cells)...
Cocoa, rich in polyphenols, has been reported to provide many health benefits due its antioxidant properties. In this study, we investigated the effect of Cocoa polyphenols extract (CPE) against oxidative stress-induced cellular senescence using a hydrogen peroxide (H
Recent studies on head and neck squamous cell carcinoma (HNSCC) tumorigenesis have revealed several dysregulated molecular pathways. The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in HNSCC, making it an attractive target for therapies. PHT-427 a dual inhibitor of PI3K the mammalian AKT/PDK1. This study evaluates anticancer efficacy loaded into polymeric nanoparticles (NP) based α-TOS (NP-427) administered by intratumoral injection hypopharyngeal (FaDu...
To evaluate vestibular restoration and the evolution of compensatory saccades in acute severe inflammatory nerve paralysis, including neuritis Ramsay Hunt syndrome with vertigo.Prospective.Tertiary referral center.Vestibular (n = 18) patients vertigo 13) were enrolled.After treatment oral corticosteroids, followed up for 6 months.Functional recovery facial was scored according to House-Brackman grading system. Caloric video head impulse tests performed every patient at time enrolment....
Presbycusis or Age-related hearing loss (ARHL) is a sensorineural that affects communication, leading to depression and social isolation. Currently, there are no effective treatments against ARHL. It known cocoa products have high levels of polyphenol content (mainly flavonoids), potent anti-inflammatory antioxidant agents with proven benefits for health. The objective determine the protective effect at cellular molecular in Presbycusis. For vitro study, we used House Ear Institute-Organ...
Background: In the suppression head impulse paradigm (SHIMP) vHIT protocol, participant is instructed to follow with his gaze a mobile target generated by laser placed on participant's head. Recent studies have reported that refixation saccade latencies are in relation time evolution of vestibular dysfunction both procedures. We hypothesized some central mechanisms like prediction could be one causes for differences saccadic eye responses. Methods: A prospective cohort non-randomized study...
The prognosis of patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) is generally poor. New treatments are required to supplement the current standard care. Paclitaxel (PTX), an effective chemotherapeutic for HNSCC, has serious side effects. A polymeric nanocarrier system was developed delivery PTX improve HNSCC treatment. This study aimed evaluate antitumor efficacy PTX-loaded nanoparticles based on α-TOS (PTX-NPs) administered by direct intratumoral injection...
This study aimed to evaluate the changes in VOR gain after intratympanic gentamicin therapy and correlate them with mid-term effects on control of vertigo, a population Menière's disease patients.The design was prospective "Outcomes research."Tertiary referral center.This included 20 patients unilateral refractory medical for at least 1 year, treated an demand protocol.Therapeutic.Audiometry, caloric testing, vHIT before beginning protocol were performed. Patients underwent weekly...
Currently, new treatments are required to supplement the current standard of care for head and neck squamous cell carcinoma (HNSCC). The phosphatidylinositol3-kinase (PI3K) signaling pathway is commonly altered activated in HNSCC. PHT-427 a dual PI3K-mammalian target AKT/PDK1 inhibitor; however, best our knowledge, effect inhibitor on HNSCC has not been investigated. This study aims evaluate antitumoral PHT-427-loaded polymeric nanoparticles based α-tocopheryl succinate (α-TOS). vitro...
Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome related to poor health outcomes old age. a potentially modifiable risk factor for Oxidative stress has been proposed key underlying onset and/or development and Cocoa high levels polyphenols provides many benefits due its antioxidant properties. Male female C57Bl/6J mice were randomly assigned two study groups: animals...
Age-related hearing loss (ARHL) or Presbycusis is the most frequent sensory deficiency in older adults and associated with comorbidities, such as falls, cognitive decline, frailty. Frailty related to poor health outcomes old age. Recent research suggested that ARHL may be a potentially modifiable risk factor for frailty, although inconclusive. The use of animal models study correlation between frailty important test future interventions translated into clinical practice. aim this was...
KEY POINTS1.Our population represents a common clinical scenario in which auditory profiles do not determine eligibility for further evaluation.2.Mean VOR gain the VS group, was significantly lower on affected side three canal planes.3.Refixation saccades horizontal had higher latency and velocity group.4. When we categorized presence of VIN with mastoid stimulation, yielded sensitivities 81.8% specificities 73.9% detecting VS.5.The test causes minor discomfort high diagnostic accuracy...