A5036327175- Protist diversity and phylogeny
- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Cystic Fibrosis Research Advances
- RNA Research and Splicing
- Cellular transport and secretion
- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2018-2022
Polish Academy of Sciences
2019-2022
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2015
Cilia beating is powered by the inner and outer dynein arms (IDAs ODAs). These multi-subunit macrocomplexes are arranged in two rows on each doublet along entire cilium length, except its distal end. To generate cilia beating, activity of ODAs IDAs must be strictly regulated locally interactions with arm-associated structures within ciliary unit coordinated globally time space between doublets axoneme. Here, we provide evidence a novel complex composed conserved WD-repeat proteins, Fap43p...
Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role radial spokes (RS), nexin links (N-DRC) dyneins (ODAs IDAs) is well established. However, how information transmitted from central apparatus to RS across other ciliary structures remains unclear. Here, we identify a complex comprising evolutionarily conserved proteins Ccdc96 Ccdc113, positioned parallel N-DRC forming connection between RS3, dynein g, N-DRC. Although Ccdc113 can...
Little is known about the RNA polymerase III (Pol III) complex assembly and its transport to nucleus. We demonstrate that a missense cold-sensitive mutation, rpc128-1007, in sequence encoding C-terminal part of second largest Pol subunit, C128, affects stability enzyme. The cellular levels nuclear concentration selected subunits were decreased rpc128-1007 cells, association between as evaluated by coimmunoprecipitation was also reduced. To identify proteins involved assembly, we performed...
Rzęski są strukturami zachowanymi w toku ewolucji, występującymi u większości Eukaryota. Ze względu na strukturę i pełnione funkcje wyróżnia się dwa typy rzęsek: nieruchome rzęski pierwotne, tworzone fazie spoczynkowej cyklu komórkowego oraz ruchome. pierwotne odpowiedzialne za odbieranie przekazywanie sygnałów ze środowiska do wnętrza komórki, natomiast ruchome umożliwiają ruch pojedynczych komórek, a organizmach wielokomórkowych, tym człowieka, przemieszczanie wydzielin lub drobin wzdłuż...