A5035427288- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Prenatal Substance Exposure Effects
- Tryptophan and brain disorders
- Computational Drug Discovery Methods
- Anesthesia and Neurotoxicity Research
- Phytochemicals and Antioxidant Activities
- Neuroscience and Neuropharmacology Research
- Fungal Biology and Applications
- Ethnobotanical and Medicinal Plants Studies
- Genomics, phytochemicals, and oxidative stress
- Enzyme Structure and Function
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Biochemical and Molecular Research
- Natural Antidiabetic Agents Studies
- Nigella sativa pharmacological applications
- Liver Disease Diagnosis and Treatment
- Seed and Plant Biochemistry
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
Khyber Medical University
2012-2025
Pakistan Council of Scientific & Industrial Research
2023-2025
Gyeongsang National University
2008-2024
Xinjiang Medical University
2023-2024
Northeast Forestry University
2024
Victorian Heart Hospital
2024
Qatar University
2024
Australian Centre for Heart Health
2024
Peking University
2020-2023
Behman Hospital
2023
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug available to directly treat the disease. In a search for against COVID-19, we have performed high-throughput x-ray crystallographic screen of two repurposing libraries main protease (M
The effect of solvent polarity on extraction yield and antioxidant properties phytochemical compounds in bean seeds was studied. Seed flour three varieties extracted a series organic solvents with increasing (n-hexane, petroleum ether, chloroform, ethyl acetate, ethanol, acetone water). Preliminary screening phytochemicals showed the presence tannins, flavonoids, cardiac glycosides, anthocyanins, terpenoids, carotenoids, ascorbic acid reducing all extracts. One way analysis variance (ANOVA)...
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases. Repeated concussion is becoming a serious public health issue with uncontrollable adverse effects the human population, which involve cognitive dysfunction even permanent disability. Here, we demonstrate that traumatic brain injury (TBI) evokes oxidative stress, disrupts homeostasis, boosts neuroinflammation, further contributes to neuronal degeneration mouse brain. We also melatonin (an anti-oxidant...
The spent black tea extract was utilized in order to synthesize the silver nanoparticles (SBT-AgNPs). Various parameters were tested yield best production of SBT-AgNPs. characterization conducted by X-Ray diffraction, Scanning electron microscopy, Zeta potential and energy dispersive X-ray (EDX). XRD analysis showed hkl planes corresponding (111), (200), (220), (311) at 2θ theta deg 38.3°, 40.8°, 64.5°, 74.2°. scanning microscopy reported plate like round shaped morphology AgNPs. zeta...
Exposure to ethanol during early development triggers severe neuronal death by activating multiple stress pathways and causes neurological disorders, such as fetal alcohol effects or syndrome. This study investigated the effect of on intracellular events that predispose developing neurons for apoptosis via calcium-mediated signaling. Although underlying molecular mechanisms neurotoxicity are not completely determined, mitochondrial dysfunction, altered calcium homeostasis apoptosis-related...
Physical or psychological stress can cause an immunologic imbalance that disturbs the central nervous system followed by neuroinflammation. The association between inflammation and depression has been widely studied in recent years, though molecular mechanism is still largely unknown. Thus, targeting signaling pathways link to neuroinflammation might be a useful strategy against depression. current study investigated protective effect of melatonin lipopolysaccharide (LPS)-induced Our results...
Recent advancements in biomarker research for the diagnosis, prognosis, and treatment strategies of major depressive disorder (MDD) have yielded significant findings that warrant documentation. The clinical demand biomarkers persists due to limited accuracy efficiency subjective diagnostic approaches. This review scrutinized papers related MDD published between January 2011 till July 2024, focusing exclusively on human studies with statistically results. compiled encompass cellular membrane...
Ischemic stroke is a severe neurological disorder with high prevalence rate in developed countries. It characterized by permanent or transient cerebral ischemia and it activates syndrome of pathological events such as membrane depolarization, glutamate excitotoxicity, intracellular calcium buildup. Carveol widely employed anti-inflammatory antioxidant traditional Chinese medicine. In the present study, neuroprotective effects post-treated carveol were demonstrated against middle artery...
SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, facilitating cleavage of viral polypeptide chain, PLpro has additional and vital function removing ubiquitin ISG15 (Interferon-stimulated gene 15) from host-cell proteins to support coronaviruses in evading host's innate immune responses. We identified three phenolic compounds bound PLpro, preventing essential molecular interactions by screening a natural compound library. The X-ray...
Silymarin is proclaimed to be a blend of flavonolignans or phytochemicals. An era new generation direct-acting antivirals (DAAs) has commenced have facet effect in swaying the hepatitis C virus (HCV). Nonetheless, this therapy serious side effects that jeopardize its efficacy. This study aimed at probing ribavirin (RBV) and sofosbuvir (SOF) along with silymarin as an adjunct on hematological parameters markers obscured oxidative stress. The DAAs was also examined variable sex hormone level...
Ribulose bisphosphate carboxylase/oxygenase (RuBisCO), is a widely available plant protein receiving great interest because of its nutritional and functional properties. It can be valuable source for vegetarians. However, it has not received commercial significance due to the lack streamlined extraction process at industrial scale, including potential health benefits. In this review, we have summarized literature on biochemical characteristics RuBisCO compared value with other proteins, as...
Exposure to alcohol during brain development may cause a neurological syndrome called fetal syndrome, characterized by pre- and postnatal growth deficiencies, craniofacial anomalies, evidence of CNS dysfunction. The objective this study was evaluate pentylenetetrazol (PTZ) ethanol effects on Bax, Bcl-2 expression, which further induced activation caspase-3, release cytochrome-c from mitochondria, observe the protective vitamin C (vit-C) against PTZ ethanol-induced apoptotic neurodegeneration...
This study employed neutral PBS buffer combined with ammonium sulfate fractionation to isolate peptide-active fractions (PD-30, PD-50, PD-80) from Cuminum cyminum L.seeds (cumin) and systematically evaluated their antimicrobial, antioxidant, hypoglycemic, anticancer activities. The results demonstrated that the PD-80 fraction exhibited potent antifungal activity against Candida albicans (inhibition zone diameter: 12.5 mm) significant antioxidant capacity, DPPH ABTS radical scavenging rates...
ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by dopaminergic neuronal loss and chronic neuroinflammation, leading to significant motor non‐motor deficits. This study explores the therapeutic potential of alpha‐linolenic acid (ALA), known antioxidant anti‐inflammatory agent, in lipopolysaccharide (LPS)‐induced murine model PD. Male Balb‐C mice were divided into control, LPS‐treated, LPS + ALA‐treated ALA‐only groups. Behavioural assessments,...
The extensive utilization of chlorpyrifos and cypermethrin in agriculture raises concerns regarding the accumulation pesticide residues human food, posing a threat to health. This study aimed investigate effect ozonation on cauliflower decrease level pesticides. Cypermethrin organophosphate were applied at specific doses. High-performance liquid chromatographic techniques employed detect cauliflower. effects common oxidizers (hydrogen peroxide, chlorine, ozone) reduction investigated....
The determination of the seven elements was performed by Perkin Elmer Atomic Absorption (AA) spectrophotometer. present study highlights importance heavy metals residual concentration including Cd, Cr, Cu, Fe, Mn, Ni and Zn in milk Camel, Cattle, Buffalo, Sheep Goat from various areas Khyber Pakhtunkhwa (KPK), Pakistan. It revealed that camel comprising high levels (5.150 ± 0.021 mg/kg), Mn (0.094 0.003 mg/kg) Fe (1.580 0.530 with a definite correlation. In buffalo, noxious Cu (0.223 0.010...