Jiale He

ORCID: 0000-0003-0902-4853
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About
Contact & Profiles
Research Areas
  • Advanced biosensing and bioanalysis techniques
  • Biosensors and Analytical Detection
  • DNA and Nucleic Acid Chemistry
  • Salivary Gland Disorders and Functions
  • Surgical Simulation and Training
  • Growth Hormone and Insulin-like Growth Factors
  • Molecular Junctions and Nanostructures
  • Soft Robotics and Applications
  • Acupuncture Treatment Research Studies
  • Diabetes and associated disorders
  • Anatomy and Medical Technology
  • Dermatology and Skin Diseases
  • Advanced Biosensing Techniques and Applications

China Academy of Chinese Medical Sciences
2024

Guang’anmen Hospital
2023

Chinese Academy of Medical Sciences & Peking Union Medical College
2023

Beijing Normal University
2018-2020

University of Illinois Urbana-Champaign
2019

Zhejiang University
2019

The complete formation of stem-loop (i.e., hairpin) configuration on chip surface is particular importance for the application hairpin DNA (hpDNA) in building biosensors various analytes with optimized performance. We report herein a convenient electrochemical protocol evaluating yield conformations upon self-assembly electrode surface. As different hydrolysis capability Exonuclease I (Exo I) toward single-stranded (ssDNA) and hpDNA, we can selectively remove ssDNA from but retain hpDNA...

10.1021/acs.analchem.8b01445 article EN Analytical Chemistry 2018-06-08

An aptamer-truncating strategy was utilized to create high-performance GO-based aptasensors for detection of multiple mycotoxins.

10.1039/c9an00624a article EN The Analyst 2019-01-01

The aim of the study was to observe effect acupuncture on regulating interleukin (IL)-17, tumor necrosis factor (TNF)-ɑ, and aquaporins (AQPs) in Sjögren's syndrome (SS) patients non-obese diabetic (NOD) models.Levels anti-AQP 1, 5, 8, 9 antibodies, IL-17, TNF-ɑ serum SS were compared prior following 20 treatment visits during 8 weeks. While murine model, five groups divided receive interventions for 4 weeks, including control, acupuncture, isoflurane, hydroxychloroquine. submaxillofacial...

10.1111/odi.14680 article EN cc-by-nc-nd Oral Diseases 2023-07-30

<title>Abstract</title> <bold>Background</bold> Abnormal activation of the interferon (IFN) signalling plays a central role in progression Sjögren’s syndrome (SS). However, causal relationship between IFN and SS remains unclear, with complex interactions existing among genetic variants, epigenetic modifications, inflammatory cytokine levels, expression IFN-associated genes. Thus, order to reveal potential causality interaction mechanisms gene expression, DNA methylation, cytokines, SS, our...

10.21203/rs.3.rs-4371628/v1 preprint EN cc-by Research Square (Research Square) 2024-05-15

Quantitative comparison of three representative staining methods for developing multichannel colorimetric biochips, which allow visual detection multiple cancer markers.

10.1039/c8ay00356d article EN Analytical Methods 2018-01-01

We report a versatile fluorometric <italic>in-situ</italic> hybridization protocol for quantifying hairpin conformations in DNA self-assembled monolayers on substrates, which facilitates the creation of hpDNA-based biosensors with optimal detection performance.

10.1039/d0an00657b article EN The Analyst 2020-01-01
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