A5021820529- HIV-related health complications and treatments
- HIV Research and Treatment
- Ziziphus Jujuba Studies and Applications
- Healthcare and Venom Research
- RNA regulation and disease
- Advanced Proteomics Techniques and Applications
- HIV/AIDS drug development and treatment
- Viral Infections and Immunology Research
- RNA and protein synthesis mechanisms
Shanghai Public Health Clinical Center
2017-2022
Background Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), has been widely used in the therapy of human immunodeficiency virus (HIV) infection. Some its toxic effects on hepatic cells have reported to display features mitochondrial dysfunction through bioenergetic stress and autophagy, etc. However, alteration protein levels, especially during treatment EFV not fully investigated. Methods We built cell model EFV-induced liver toxicity treating Huh-7 with different...
Enterovirus A71 (EV71) infection can cause hand, foot, and mouth disease (HFMD) severe neurological complications in children. However, the biological processes regulated by EV71 remain poorly understood. Herein, proteomics metabonomics studies were conducted to uncover mechanism of rhabdomyosarcoma (RD) cells identify potential drug targets. Differential expressed proteins from enriched membrane analyzed isobaric tags for relative absolute quantitation (iTRAQ)-based technology. Twenty-six...