Bliss Buttery
A5015736340- Neuroblastoma Research and Treatments
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Cell death mechanisms and regulation
- Insect-Plant Interactions and Control
Rothamsted Research
2020
Institute of Cancer Research
2019
Abstract The evolution of resistance to drugs and pesticides poses a major threat human health food security. Neonicotinoids are highly effective insecticides used control agricultural pests. They target the insect nicotinic acetylcholine receptor mutations that confer have been slow develop, with only one field‐evolved mutation being reported date. This is an arginine‐to‐threonine substitution at position 81 nAChR_β1 subunit in neonicotinoid‐resistant aphids. To validate role R81T...
Neuroblastoma is a pediatric cancer that frequently metastatic and resistant to conventional treatment. In part, lack of natively metastatic, chemoresistant
<div>Abstract<p>Neuroblastoma is a pediatric cancer that frequently metastatic and resistant to conventional treatment. In part, lack of natively metastatic, chemoresistant <i>in vivo</i> models has limited our insight into the development aggressive disease. The Th-<i>MYCN</i> genetically engineered mouse model develops rapidly progressive chemosensitive neuroblastoma lacks clinically relevant metastases. To study tumor progression in context more...
<p>Resistant tumors show recurrent copy number aberrations and a tendency towards the neuroblastoma mesenchymal gene expression signature.</p>
<p>Supplementary materials and methods Supplementary figures legends</p>
<p>Th-MYCNCPM32 tumors and cell lines show enhanced nuclear STAT3 staining sensitivity to CYT387.</p>
<p>Exogenous manipulation of STAT3 levels partially mimics the effect CYT387, Th-MYCNCPM32 cell lines show cross resistance to front line chemotherapy.</p>
<p>Th-MYCNCPM32 tumors and derived cell lines show enhancement of mesenchymal markers.</p>
<p>Resistant tumors show recurrent copy number aberrations and a tendency towards the neuroblastoma mesenchymal gene expression signature.</p>
<p>Cyclophosphamide is associated with cell death and actively metabolized in both sensitive resistant mice.</p>
<p>Th-MYCNCPM32 tumors show increased ECM and levels of Tnrc6 but not TK1.</p>
<p>Th-MYCNCPM32 tumors and cell lines show enhanced nuclear STAT3 staining sensitivity to CYT387.</p>
<p>Th-MYCNCPM32 tumors and derived cell lines show enhancement of mesenchymal markers.</p>
<p>Exogenous manipulation of STAT3 levels partially mimics the effect CYT387, Th-MYCNCPM32 cell lines show cross resistance to front line chemotherapy.</p>
<p>Cyclophosphamide is associated with cell death and actively metabolized in both sensitive resistant mice.</p>
<p>Supplementary materials and methods Supplementary figures legends</p>
<p>Th-MYCNCPM32 tumors show increased ECM and levels of Tnrc6 but not TK1.</p>
<div>Abstract<p>Neuroblastoma is a pediatric cancer that frequently metastatic and resistant to conventional treatment. In part, lack of natively metastatic, chemoresistant <i>in vivo</i> models has limited our insight into the development aggressive disease. The Th-<i>MYCN</i> genetically engineered mouse model develops rapidly progressive chemosensitive neuroblastoma lacks clinically relevant metastases. To study tumor progression in context more...