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Peipei Zhang

ORCID: 0000-0003-0918-0610
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About
Contact & Profiles
A5102851924
Research Areas
  • Skin and Cellular Biology Research
  • Cell Adhesion Molecules Research
  • Silk-based biomaterials and applications
  • Nail Diseases and Treatments
  • Hair Growth and Disorders
 In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial
OPENALEX - Publications 
Irina Gurevich Pooja Agarwal Peipei Zhang J. Dolorito Stacie Oliver and 14 more Henry Liu Nicholas Reitze Nikhil Sarma Işın Sinem Bağcı Kunju Sridhar Visesha Kakarla V.K. Yenamandra Mark E. O’Malley Marco di Prisco Sara F. Tufa Douglas R. Keene Andrew P. South Suma Krishnan M. Peter Marinkovich

Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is a lifelong genodermatosis associated with blistering, wounding, and scarring caused by mutations in COL7A1 , the gene encoding anchoring fibril component, collagen VII (C7). Here, we evaluated beremagene geperpavec (B-VEC), an engineered, non-replicating containing herpes simplex virus type 1 (HSV-1) vector, to treat RDEB skin. B-VEC restored C7 expression keratinocytes, fibroblasts, mice human xenografts. Subsequently,...

10.1038/s41591-022-01737-y article EN cc-by Nature Medicine 2022-03-28
 Preclinical Evaluation of a Modified Herpes Simplex Virus Type 1 Vector Encoding Human TGM1 for the Treatment of Autosomal Recessive Congenital Ichthyosis
OPENALEX - Publications 
John C. Freedman Trevor J. Parry Peipei Zhang Avijit Majumdar Suma Krishnan and 6 more Lauren K. Regula Mark E. O’Malley Sarah Coghlan S.D. Yogesha Sureshkumar Ramasamy Pooja Agarwal

10.1016/j.jid.2020.07.035 article EN publisher-specific-oa Journal of Investigative Dermatology 2020-09-22
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