Radiotherapy, a mainstay of first-line cancer treatment, suffers from its high-dose radiation-induced systemic toxicity and radioresistance caused by the immunosuppressive tumor microenvironment. The synergy between radiosensitization immunomodulation may overcome these obstacles for advanced radiotherapy. Here, authors propose cooperated with stimulator interferon genes (STING) pathway activation strategy fabricating novel lanthanide-doped radiosensitizer-based metal-phenolic network,...

Abstract Photothermal therapy (PTT), one of the most‐potent cancer therapeutic strategies known, is highlighted with excessive inflammatory response, while ablating immunogenic death. This hyperactive immune response may override PTT‐triggered immunogenicity, exacerbate skin empyrosis, and incur permanent tissue injury high‐profile tumor regeneration. Therefore, an anticancer balance between pathological protective urgently needed for advanced photothermal tactic. Herein, a gas‐modulated...

Nanomedicine has revolutionized cancer therapeutic strategies but not completely changed the outcomes of tricky tumors that evolve a sophisticated immunosuppressive tumor microenvironment (TME) such as acidification. Here, metal-phenolic network-based nanocomplex embedded with lactate oxidase (LOX) and mitochondrial respiration inhibitor atovaquone (ATO) was constructed for TME remodeling sonodynamic therapy (SDT). In this nanocomplex, sonosensitizer chlorin e6-conjugated polyphenol...

Abstract Radiotherapy (RT) is hampered by the limited oxygen in tumors, which could be potentiated via reprogramming metabolism and increasing utilization efficiency. Herein, a metal‐phenolic nanosensitizer (Hf‐PSP‐DTC@PLX) was integrated an acid‐sensitive hydrogen sulfide (H 2 S) donor (polyethylene glycol‐co‐polydithiocarbamates, PEG‐DTC) hafnium‐chelated polyphenolic semiconducting polymer (Hf‐PSP) amphiphilic (poloxamer F127, PLX). Hf‐PSP‐DTC@PLX elicited high imaging performance for...

Abstract Radiotherapy (RT) based on DNA damage and reactive oxygen species (ROS) generation has been clinically validated in various types of cancer. However, high dose‐dependent induced toxicity to tissues, non‐selectivity, radioresistance greatly limit the application RT. Herein, an oxygen‐enriched X‐ray nanoprocessor Hb@Hf‐Ce6 nanoparticle is developed for improving therapeutic effect RT‐radiodynamic therapy (RDT), enhancing modulation hypoxia tumor microenvironment (TME) promoting...

Phototherapy is a light-triggered treatment for tumor ablation and growth inhibition via photodynamic therapy (PDT) photothermal (PTT). Despite extensive studies in this area, major challenge the lack of selective effective phototherapy agents that can specifically accumulate tumors to reach therapeutic concentration. Although recent attempts have produced photosensitizers complexed with nanomaterials, tedious preparation steps poor efficiency still hampers broad utilization these...

Tumor hypoxia is believed to be a factor limiting successful outcomes of oxygen-consuming cancer therapy, thereby reducing patient survival. A key strategy overcome tumor increase the prevalence oxygen at site. Oxygen-containing microbubbles/nanobubbles have been developed supply and enhance effects therapies such as radiotherapy photodynamic therapy. However, application these bubbles constrained by their poor stability, requiring major workarounds half-lives. In this study, we explore...

Abstract The oxide thermoelectric (TE) ceramics have continued to attract the focus due their high stability and low cost. However, TE performance falls obviously backward with typical compounds such as PbTe. Here, we revealed reason for difficulty of optimized is large electronegativity difference between metal O ions in oxide, which results strong electron localization bond energy. former leads unfavorable electrical properties latter a lattice thermal conductivity. Focusing on these...

Optical signals with distinctive properties, such as contactless, fast response, and high identification, are harnessed to realize advanced anti-counterfeiting. However, the simultaneous attainment of multi-color, -temporal, -modal luminescence performance remains a compelling imperative pursuit. In our work, temperature/photon-responded dynamic self-activated originating from nonstoichiometric Zn2GeO4 is developed modulation intrinsic defects. The increased concentration oxygen vacancies...

Abstract Stress response to radiation sensitizes immunologically nonresponsive tumors cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) therapy. The combination of radiotherapy (RT) and CTLA‐4 immune checkpoint blockade therapy has been clinically adopted yielded outstanding cooperative effects from restricted local lethality systemic response. However, this induces resistance caused by T cell depletion increased programmed death‐ligand 1 (PD‐L1) expression in tumor cells. Hence,...

Abstract The development of highly stable and ultra‐long organic room temperature phosphorescence (RTP) materials holds great promise for applications in anti‐counterfeiting information protection. To improve the encryption level, exploration with tunable afterglow features is urgent need. Hereby, a series long‐lived systems RTP developed by incorporating benzocarbazole derivatives into polyvinyl alcohol (PVA) matrix (BCz@PVA). Notably, BCz@PVA film exhibits outstanding behavior an ultralong...

Inorganic materials doped with chromium (Cr) ions generate remarkable and adjustable broadband near-infrared (NIR) light, offering promising applications in the fields of imaging night vision technology. However, achieving high efficiency thermal stability these NIR phosphors poses a significant challenge for their practical application. Here, we employ crystal field engineering to modulate characteristics Cr3+-doped Gd3Ga5O12 (GGG). The Gd3MgxGa5–2xGexO12 (GMGG):7.5% Cr3+ (x = 0, 0.05,...

Photodynamic therapy (PDT) is a novel treatment modality that under intensive preclinical investigations for variety of diseases, including cancer. Despite extensive studies in this area, selective and effective photodynamic agents can specifically accumulate tumors to reach therapeutic concentration are limited. Although recent attempts have produced photosensitizers (PSs) complexed with various nanomaterials, the tedious preparation steps poor tumor efficiency hamper their utilization....

Nanobubbles, as a kind of new ultrasound contrast agent (UCAs), have shown promise to penetrate tumor vasculature allow for targeted imaging. However, their inherent physical instability is an ongoing concern that could weaken imaging ability with ultrasound. Gas vesicles (GVs), which are genetically encoded, naturally stable nanostructures, been developed the first ultrasonic biomolecular reporters showed strong enhancement. further development GVs limited by quick clearance...

The productivity analysis of cable crane transportation in the construction field is great significance to improve equipment management and reduce operation costs. However, traditional manual recording method analyzing time-consuming tedious. existing vision-based requires significant amounts time collect extensive images at sites does not achieve high-precision detection complex scenes. Thus, an automated for proposed using a new synthetic image approach based on augmented reality (AR)...

Chemotherapy is a standard care for cancer management, but the lack of tumor targeting and high dose-induced side effects still limit its utility in patients. Here, we report chemotherapy combined with photothermal therapy (PTT) enhanced ablation by functionalization gold nanorods (GNRs) novel small molecule named truncated Evans blue (tEB). On basis binding affinity tEB albumin, an Abraxane-like nanodrug, human serum albumin/hydroxycamptothecin (HSA/HCPT), was further complexed GNR-tEB....

Malignant melanoma cell-intrinsic PD-1:PD-L1 interaction thrusts tumorigenesis, angiogenesis, and radioresistance via mTOR hyperactivation to aggravate circumjacent aggression. Interdicting intrinsic growth signals, including the blockade of PD-L1 signaling concurrently, cooperative with radiotherapy may provide a vigorous repertoire alleviate tumor encumbrance. Thence, we design three-pronged platinum@polymer-catechol nanobraker deliver inhibitor TAK228 anti-PD-L1 antibody (aPD-L1) for...

Abstract The tumor hypoxic microenvironment is a dynamic status that closely related to growth, metastasis, clearance, and recurrence. Hypoxic conditions are present in almost all tumors, which greatly reduce the clinical effects of therapy. Considering physical tolerance dose‐related side cancer radiotherapy (RT) patients, herein, universal two‐step strategy designed based on safe, noninvasive, deep penetration, intensity‐controlled ultrasound method alleviate hypoxia enhance RT. first step...

PA/FI/MRI imaging guided Glypican-3 targeted hepatocellular carcinoma photothermal therapy mediated by Fe₃O₄ Core/Au shell nanocomplex.

Photothermal therapy (PTT) achieves substantive therapeutic progress in certain tumor types without exogenous agents but is hampered by the over-activated inflammatory response or recurrence some cases. Herein, we technically developed metal-polyphenolic nanosystem with precise NIR-II fluorescence-imaging guidance for combining hafnium (Hf)-sensitized radiotherapy PTT to regress growth.

Combination therapy is a promising approach to promote the efficacy and reduce systemic toxicity of cancer therapy. Herein, we examined potency combined chemo-phototherapy by constructing hyaluronidase- reactive oxygen species-responsive hyaluronic acid nanoparticle carrying chemotherapy drug photosensitizer in tumor-bearing mouse model. We hypothesized that following decomposition, drugs inside nanocomplex will be released tumors provide effective tumor treatment. aimed design smart...