A5090209462- Coconut Research and Applications
- Tuberculosis Research and Epidemiology
- Chemical Reactions and Isotopes
- Pneumocystis jirovecii pneumonia detection and treatment
- Pickering emulsions and particle stabilization
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Synthesis and Reactions of Organic Compounds
- Dyeing and Modifying Textile Fibers
- Synthesis and biological activity
- Fatty Acid Research and Health
- Essential Oils and Antimicrobial Activity
Engelhardt Institute of Molecular Biology
2023-2024
MIREA - Russian Technological University
2021-2023
The mechanisms of action pyrimidine nucleoside derivatives on model lipid membranes various compositions were studied. A systematic analysis the tested agents’ effects membrane physicochemical properties was performed. Differential scanning microcalorimetry data indicated that ability to disorder lipids depended types bases and membrane-forming lipids. 5′-norcarbocyclic uracil found be ineffective, while N4-alkylcytidines demonstrated most pronounced effects, significantly decreasing...
Objectives . With the growing resistance of pathogenic microorganisms to antibiotics, development new antimicrobial drugs offering specific mechanisms action becomes an urgent task. Only few antimicrobials offer a broad spectrum activity against gram-positive and gram-negative bacteria, molds, yeasts. In this regard, purpose work was develop methods for synthesizing biologically active derivatives alkyl-substituted phenols (reactions at hydroxy group) study their biological effect. Methods...
Unsaturated fatty acids, such as oleic acid (OA) and linoleic (LA), are promising antimicrobial cytostatic agents. We modified OA LA with thymol (TOA TLA, respectively) to expand their bioavailability, stability, possible applications, encapsulated these derivatives in polymeric nanoparticles (TOA-NPs TLA-NPs, respectively). Prior synthesis, we performed mathematical simulations PASS ADMETlab 2.0 predict the biological activity pharmacokinetics of TOA TLA. TLA were synthesized via...
Objectives. This study investigated the surface properties and micelle formation of combined stabilizers, which are a mixture ionic nonionic surfactants or different surfactants, to establish correlation between composition stabilizers colloidal–chemical direct emulsions obtained in their presence. Methods. The tension at interface aqueous solutions with air toluene was measured using digital tensiometer. sedimentation stability assessed by volume exfoliated water oil phases for seven days....