A5090716324- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Organ Transplantation Techniques and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Anesthesia and Neurotoxicity Research
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
University of Verona
2016-2025
Azienda Ospedaliera Universitaria Integrata Verona
2021-2025
Clínica Girona
2023
University of Turin
2023
Società Italiana di Cardiologia
2022
Miami Heart Research Institute
2020
St. John Hospital & Medical Center
2017
Azienda Ospedaliero Universitaria San Giovanni Battista
2011-2015
October 6 University
2014
Fundación Juan March
2014
1. The effects of phosphate and protons on the mechanics energetics muscle contraction have been investigated using glycerinated rabbit psoas muscle. 2. Fibres were fully activated by addition Ca2+ (pCa 4‐5) at 10 degrees C. velocities measured in isotonic load clamps, unloaded fibres applying a series step changes fibre length. Fibre ATPase activity was monitored an enzyme system to couple ADP production reduced nicotinamide‐adenine dinucleotide (NADH) measuring depletion NADH optical...
In this work we performed an imaged-based computational study of the systolic fluid dynamics in presence mitral valve regurgitation (MVR). particular, compared healthy and different regurgitant scenarios with aim quantifying hemodynamic quantities.We dynamic (CFD) simulations left ventricle, atrium aortic root, a resistive immersed method, turbulence model, imposed wall motion reconstructed from Cine-MRI images, which allowed us to segment also valve. For considered increase heart rate...
Accurate reconstruction of the right heart geometry and motion from time-resolved medical images is crucial for diagnostic enhancement computational analysis cardiac blood dynamics. Commonly used segmentation and/or techniques, exclusively relying on short-axis cine-MRI, lack precision in critical regions heart, such as ventricular base outflow tract, due to its unique morphology motion. Furthermore, procedure time-consuming necessitates significant manual intervention generating domains....
Background— The Ross operation is an alternative to mechanical aortic valve replacement in the young. Early dilatation of pulmonary autograft root exposed systemic circulation has been reported. To define prevalence of, risk factors for, and consequences late dilatation, outcome all consecutive patients operated since May 1994 was reviewed. Methods Results— Ninety one patients, 77 males 14 females, with at least 1 year follow-up underwent cross-sectional clinical echocardiographic...
Abstract In bicuspid aortic valve (BAV) disease, the role of genetic and hemodynamic factors influencing ascending pathology is controversial. To test effect BAV geometry on flow, a finite element analysis was undertaken. A surface model root aorta obtained from magnetic resonance images patients with tricuspid using segmentation facilities image processing code Vascular Modeling Toolkit (developed at Mario Negri Institute). Analytical models (antero‐posterior [AP], type 1 latero‐lateral, 2...
<h3>Objective</h3> Children undergoing Ross operation were expected to have longer autograft, but shorter homograft durability compared with adults. In order define the outcome in second decade after children, a nationwide review of 23 years experience was undertaken. <h3>Methods</h3> 305 children underwent 11 paediatric units between 1990 and 2012. Age at surgery 9.4±5.7 years, indication aortic stenosis 103 patients, regurgitation 109 mixed lesion 93. 116 (38%) patients had prior...
Extracorporeal circulation contributes to morbidity after open-heart surgery by causing a systemic inflammatory reaction. Modified ultrafiltration is technique able remove the fluid overload and mediators associated with use of cardiopulmonary bypass. It has been shown reduce cardiac operations in children, but impact on adult procedures unknown.Five hundred seventy-three consecutive patients were prospectively randomized either bypass (treatment) or no (control). Parsonnet score was used...
BACKGROUND We performed a comparative study on Ca2+ release activity of the sarcoplasmic reticulum and calcium sensitivity contractile apparatus chemically skinned myocardial fibers obtained from four nonfailing human hearts 13 excised patients with idiopathic dilated cardiomyopathy. METHODS AND RESULTS was studied by following isometric tension developed challenged solutions decreasing pCa. monitored indirectly measurement caffeine. observed no significant difference cooperativity between...
Abstract In this work, we performed a computational image-based study of blood dynamics in the whole left heart, both healthy subject and patient with mitral valve regurgitation. We elaborated multi-series cine-MRI aim reconstructing geometry corresponding motion ventricle, atrium, aortic valves, root subjects. This allowed us to prescribe such simulations where, for first time, heart is considered, allowing obtain reliable subject-specific information. The final investigate compare between...
Abstract Bicuspid aortic valve (BAV) predisposes to aneurysms with a high prevalence. A first hypothesis for this phenomenon is related fibrillin deficiency (genetic hypothesis). The present article focused on complementary, hemodynamic stating that it the peculiar fluid dynamics of blood in ascending aorta patients BAV configurations leads aneurysm formation. To corroborate hypothesis, parametric study was performed based numerical simulations hemodynamics different orifice area and...
Background White blood cell count, which is inexpensive and widely available in clinical practice, has been proposed to provide prognostic information coronary artery disease (CAD). Elevated levels of white subtypes may play different roles atherothrombosis predict cardiovascular outcomes. Methods Results The association between counts mortality was evaluated 823 subjects with angiographically demonstrated clinically stable CAD an observational-longitudinal study. correlation among factor II...
Objective: Controversy still exists about averting expenditure of health care resources on the growing elderly population.This study evaluates clinical outcome patients aged 75 years and older operated upon for acute type A aortic dissection.Methods: Between January 1990 April 2004, 247 undergoing emergency operation dissection at our Institution, 40 (16%) were (mean 78 AE 3 years, range 75-88 years) represent population.On admission, 9 (22.5%) had cardiogenic shock/ hypotension, 20 (50%)...
Background and Objective: Sphingosine 1-Phosphate (S1P), S1P receptor modulator fingolimod have been suggested to play important cardioprotective role in animal models of myocardial ischemia/reperfusion injuries. To deeply understand the function its mechanism vivo, we analyse apoptotic, inflammatory biomarkers, fibrosis vivo heterotrophic rat transplantation model. Methods: Heterotopic heart is performed 60 Sprague–Dawley (SD) rats (350-400 grams). The total n=60 transplant recipients are...