A5041220297- Microbial Natural Products and Biosynthesis
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Drug Transport and Resistance Mechanisms
- Fungal Biology and Applications
- Nanoparticles: synthesis and applications
- Infective Endocarditis Diagnosis and Management
- Advanced biosensing and bioanalysis techniques
- Bacterial biofilms and quorum sensing
- Essential Oils and Antimicrobial Activity
- Electrochemical sensors and biosensors
- Nanomaterials for catalytic reactions
- Antimicrobial Resistance in Staphylococcus
- Natural product bioactivities and synthesis
- Diet and metabolism studies
- Electrochemical Analysis and Applications
- Allelopathy and phytotoxic interactions
- Plant Pathogens and Fungal Diseases
- Spondyloarthritis Studies and Treatments
- Graphene and Nanomaterials Applications
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Plant-Microbe Interactions and Immunity
- Multicomponent Synthesis of Heterocycles
- bioluminescence and chemiluminescence research
Central University of Haryana
2020-2025
Karunya University
2025
Central University of South Bihar
2015-2021
Jawaharlal Nehru University
2008-2012
Leibniz Institute for Neurobiology
2010
Indian Agricultural Research Institute
2002
All India Institute of Medical Sciences
1991
Multicomponent reactions have long been recognized as some of the most versatile tools in organic chemistry, with extensive applications biomedical science and pharmaceutical industry. In this study, we explored potential Passerini reaction by designing synthesizing new low molecular mass gelators that can serve novel formulations for prolonged anesthesia. These address critical issues like poor solubility, bioavailability, short plasma half‐life, all which hinder therapeutic efficacy. To...
Summary. Fluoride was orally administered to rabbits at 10 mg NaF/kg body weight for 18 or 29 months. The animals were then killed and the structure of testis, epididymis vas deferens studied under light scanning electron microscopes. In treated months, spermatogenic cells in seminiferous tubules disrupted, degenerated devoid spermatozoa. loss cilia on epithelial lining lumen ductuli efferentes caput epididymidis stereocilia observed. some regions deferens, boundaries not clear appeared be...
ABSTRACT Echinocandin B (ECB) is the precursor of a first‐line antifungal, anidulafungin, widely used to treat systemic and invasive fungal infections in nosocomial community‐acquired settings. This potent antifungal naturally synthesized Aspergillus nidulans trace amounts, which can be improved by optimizing growth physiological conditions. The current study focused on fermentation medium employing statistical artificial neural network (ANN)‐based model improve ECB activity broth. In...
A major multidrug transporter, MDR1 (multidrug resistance 1), a member of the MFS (major facilitator superfamily), invariably contributes to an increased efflux commonly used azoles and thus corroborates their direct involvement in MDR Candida albicans. The Mdr1 protein has two transmembrane domains, each comprising six helices, interconnected with extracellular loops ICLs (intracellular loops). introduction deletions insertions through mutagenesis was address role largest interdomain ICL3...
The bacterial infections have been substantially increasing with higher mortality and new regimens required for their management. present work deals the green synthesis of silver nanoparticles (AgNPs) using leaf extract Pteris vittata at pH 9.0. AgNPs showed a single absorption peak 407 nm. morphology was found to be spherical in shape analyzed by scanning electron micrographs. X-ray diffraction studies revealed face-centered cubic structure 17-nm average crystallite size. They antimicrobial...
ATP-Binding cassette (ABC) transporters play an extensive role in the translocation of diverse sets biologically important molecules across membrane. EchnocandinB (antifungal) and EcdL protein Aspergillus rugulosus are encoded by same cluster genes. Co-expression echinocandinB reflects tightly linked biological functions. belongs to Multidrug Resistance associated Protein (MRP) subfamily ABC with extra transmembrane domain zero (TMD0). Complete structure MRP comprising TMD0 domain, at atomic...
A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. 15 16 were prepared cycloaddition strategy propargylated at N-1 to afford compounds 17 18. Cu-catalyzed reaction these β-lactams 18 with different aryl azides provided 1,2,3-triazole 6 7, respectively. The products fully characterized spectroscopically tested against Gram-(+) Gram-(-) bacteria. Compound 7a 7c found be most active.
Staphylococcus aureus is a notorious pathogen which often causes nosocomial and community attained infections. These infections steadily increased after evolving the resistance due to indecorous practice of antibiotics now become serious health issue. Ouabain Na+/K+-ATPase inhibitor that leads increase heart contraction in patients with congestive failure.In present study, vitro antimicrobial effect ouabain together aminoglycosides was determined against clinical non-clinical S. strains....