A5066373870- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Pain Management and Placebo Effect
- Apelin-related biomedical research
- Adipose Tissue and Metabolism
- Ophthalmology and Eye Disorders
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Ion Channels and Receptors
- Tryptophan and brain disorders
- Entomological Studies and Ecology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Regulation of Appetite and Obesity
- Thyroid Disorders and Treatments
- Pharmacological Effects and Assays
- Healthcare and Venom Research
- Pharmacology and Obesity Treatment
Universidade Federal de Alfenas
2022-2025
Universidade Estadual Paulista (Unesp)
2025
Universidade de São Paulo
2014-2024
Instituto de Neurociências e Comportamento
2015-2024
Universidade de Ribeirão Preto
2015
SUPERA Park of Innovation and Technology of Ribeirão Preto
2012
Chronic postoperative pain (CPOP) is among the main consequences of surgical procedures, directly affecting quality life. Although many strategies have been used to treat this symptom, they are often ineffective. Thus, studies investigating CPOP-associated mechanisms may help develop more effective treatment strategies. Therefore, present study investigated spinal participation transient potential receptor vanilloid type 1 (TRPV1) and PI3K/AKT/mTOR pathway activation during CPOP. In C57BL/6...
There is a controversy regarding the key role played by opioid peptide neurotransmission in modulation of panic-attack-related responses.Using prey versus rattlesnakes paradigm, present work investigated involvement endogenous peptide-mediated system inferior colliculus panic attack-related responses.Wistar rats were pretreated with intracollicular administration either physiological saline or naloxone at different concentrations and confronted ( Crotalus durissus terrificus). The...
Previous studies suggested that Cg1 area of the cingulate cortex rats controls glutamate-mediated fear-induced defensive behaviour and antinociception organised at posterior hypothalamus. In turn, microinjection nitric oxide donor SIN-1 into anterior hypothalamus mice produced behaviours antinociception. However, it remains unknown whether also modulates latter mechanisms in mice.The present study examined influence on SIN1-evoked fear-like behavioural antinociceptive responses to (300 nmol)...
We investigated the participation of nucleus tractus solitarius (NTS) in tonic‒clonic seizures and postictal antinociception control mediated by NMDA receptors, role NTS GABAergic interneurons noradrenergic pathways from locus coeruleus (LC) these phenomena. The NTS-lateral reticularis paragigantocellularis (lPGi)-LC pathway was studied evaluating neural tract tracer deposits lPGi. receptors agonists antagonists were microinjected into NTS, followed pharmacologically induced seizures....
The endogenous opioid peptide system has been implicated in the neural modulation of fear and anxiety organised by dorsal midbrain. Furthermore, previous results indicate a fundamental role played inferior colliculus (IC) mechanisms during expression defensive behaviours, but involvement IC µ1-opioid receptor anxiety- panic attack-related behaviours remains unclear. Using prey-versus-snake confrontation paradigm, we sought to investigate effects blockade on behaviour displayed rats dangerous...
The purpose of this study was to investigate whether the panicolytic‑like effect different doses anandamide microinjected into anterior hypothalamus (AH) follows same pattern a bell‑shaped dose‑response curve observed with dose treatment in dorsomedial and ventromedial hypothalamus. We investigated assumption by administering cannabinoid vanilloid receptor agonist mice exposing them real threatening situation using our experimental model based on confrontations between rodents wild snakes....
ABSTRACT This study investigated the intrinsic connections of a key‐structure endogenous pain inhibitory system, pedunculopontine tegmental nucleus (PPTN), in post‐ictal antinociceptive process through synaptic inactivation PPTN with cobalt chloride. Male Wistar rats ( n = 6 or 7 per group), weighing 250–280 g, had tail‐flick baseline recorded and were submitted to stereotaxic surgery for introduction guide‐cannula aiming at PPTN. After 5 days postoperative recovery, chloride (1 mM/0.2 µL)...
Abstract The dorsal midbrain comprises columns of the periaqueductal grey matter and corpora quadrigemina. These structures are rich in beta-endorphinergic leu-enkephalinergic neurons receive GABAergic inputs from substantia nigra pars reticulata. Although inferior colliculus (IC) is mainly involved acoustic pathways, electrical chemical stimulation central pericentral nuclei IC elicits a vigorous defensive behaviour. immobility escape elicited by activation commonly related to panic-like...