A5038062108- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Minimally Invasive Surgical Techniques
- Gynecological conditions and treatments
- Surgical Simulation and Training
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Cardiac, Anesthesia and Surgical Outcomes
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Diversity and Career in Medicine
- Innovations in Medical Education
- Pelvic and Acetabular Injuries
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Ureteral procedures and complications
- Endometrial and Cervical Cancer Treatments
- Intestinal and Peritoneal Adhesions
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Appendicitis Diagnosis and Management
- Hospital Admissions and Outcomes
- Pelvic floor disorders treatments
- Hernia repair and management
Northwestern Memorial Hospital
2006-2025
Northwestern University
2016-2025
Northwestern Medicine
2018-2025
Cairo University
2025
Center for Special Minimally Invasive and Robotic Surgery
2024
NewYork–Presbyterian Brooklyn Methodist Hospital
2023
RELX Group (United States)
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2023
Faculty of 1000 (United States)
2023
Harvard University
2018-2022
Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue endometriosis play critical physiologic roles. We found that mRNA protein levels estrogen receptor 2 (ESR2) were strikingly higher, whereas 1 (ESR1), total progesterone (PGR), B (PGR B) significantly lower endometriotic versus endometrial cells. Because ESR2 displayed most striking differential expression between cells, mechanisms for this difference are unknown, we tested hypothesis alteration DNA...
Endometriosis is an estrogen-dependent disease. Steroidogenic factor-1 (SF-1), a transcriptional factor essential for activation of multiple steroidogenic genes estrogen biosynthesis, undetectable in normal endometrial stromal cells and aberrantly expressed endometriotic cells.The objective the study was to unravel mechanism differential SF-1 expression cells.We identified CpG island flanking promoter exon I region determined its methylation patterns conducted at Northwestern...
Estradiol and its nuclear receptors, estrogen receptor (ER) alpha ERbeta, play critical roles in endometrium endometriosis. Levels of due to pathological hypomethylation promoter, are significantly higher endometriotic vs. endometrial tissue stromal cells, whereas ERalpha levels lower regulates gene expression via alternatively used promoters A, B, C.The aim the study was determine whether high ERbeta cells from ovarian endometriomas regulate expression.ERbeta knockdown increased mRNA...
ObjectiveTo assess the cellular and molecular landscape of adenomyosis.DesignSingle-cell analysis genome-wide messenger RNA (mRNA) expression (single-cell sequencing) matched tissues endometrium, adenomyosis, myometrium using relatively large numbers viable cells.SettingNot applicable.Patient(s)Patients (n = 3, age range 40–44 years) undergoing hysterectomy for diffuse adenomyosis.Main Outcome Measure(s)Definition adenomyotic, endometrial myometrial from same uterus single-cell sequencing...
Retinoic acid (RA) controls multiple biological processes via exerting opposing effects on cell survival. Retinol uptake into cells is controlled by stimulated RA 6 (STRA6). then produced from retinol in the cytosol. Partitioning of between nuclear receptors receptor α and peroxisome-proliferator-activated β/δ regulated cytosol-to-nuclear shuttling proteins cellular binding protein 2 (CRABP2) fatty 5 (FABP5), which induce apoptosis or enhance survival, respectively. The roles these...
To examine the effect of a preoperative transversus abdominis plane infiltration on postoperative quality recovery and analgesia in patients undergoing laparoscopic hysterectomy.The study was randomized, double-blinded, placebo-controlled trial. Seventy-five healthy women were randomized to receive with 0.5% ropivacaine, 0.25% or saline. Postoperative score (QoR-40), pain, opioid consumption assessed up 24 hours after surgical procedure. Data analyzed using Kruskal-Wallis test. Post hoc...