Abstract. The aim of this review is to characterize the epidemiology, determine phenotypes and endotypes anaphylaxis, pathogenetic mechanisms its development, systematize on their basis clinical manifestations degrees severity condition, evaluate possible biomarkers anaphylaxis for wider implementation in practice. Anaphylaxis most severe allergic reactions, putting patients at high risk losing lives requiring prompt recognition immediate treatment. However, since symptoms mimic other...

Abstract. Allergen-specific immunotherapy (ASIT) is the only available treatment method aimed at pathophysiology of allergic diseases, which can modify course disease. However, in case hypersensitivity to dog allergens, data on effectiveness ASIT are contradictory. The aim study: study patients with rhinitis (AR) and/or bronchial asthma (BA) and allergens. Materials methods. level specific IgG4 (sIgG4) extract allergens was determined before one year after start treatment, results a...

Abstract. The aim of this review is to systematize and consider the biomarkers anaphylaxis for their widespread clinical use, which will make diagnosis disease early accurate, treatment more effective. A new classification based on precision medicine using phenotypes, endotypes has expanded Ph. Gell R. Coomb’s better identify treat anaphylaxis. Skin tests, determination specific IgE, allergen component diagnostics are safe tools detection sensitization numerous allergens, especially in...

Abstract. The aim of the review is to detail triggers anaphylaxis, in particular drugs such as antibiotics, chemopreparations, monoclonal antibodies, anesthetics and neuromuscular blockers, β-blockers ACE inhibitors, influence cofactors, mastocytosis clonal mast cell disorders on incidence anaphylaxis. It important provide allergists medical professionals with knowledge about new approaches management patients which will improve its diagnosis, treatment prevention. presence anaphylaxis are...

BACKGROUND. Like any other drug, chemotherapy drugs can cause hypersensitivity reactions and are the third leading of drug-induced anaphylaxis deaths in United States. Timely detection to chemotherapeutic oncology is extremely important because, unlike (for example, antibiotics or anesthetics), which be relatively easily replaced by others, often unique indispensable for treatment neoplasms. In such situations, doctor should evaluate benefits continuing comparison with risk a potentially...

Abstract. Respiratory allergic diseases, which include rhinitis and bronchial asthma, are a serious medical social problem worldwide due to their high prevalence negative impact on the quality of life relevant category patients. The development respiratory allergy pathology is usually caused by inhaled allergens, divided into seasonal: tree, grass or weed pollen, as well year-round — house dust mites, mold, pet epithelium. But at same time, manifestations often combined with its...

SENSITIZATION TO PET ALLERGENS AMONG THE PATIENTS OF ALLERGOLOGIC CLINIC M. A. Lykova Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine KIA «Forpost», Abstract. The aim: to study the prevalence and structure sensitization pet allergens among patients allergy clinic. Material methods research. results a multiplex (determination specific IgE 112 allergenic proteins using ImmunoCap ISAC test system) in 553 who came immunology allergology clinic "Forpost" with complaints...

HYPERSENSITIVITY TO DOG ALLERGENS (CLINICAL CASES) M. A. Lykova Shupyk National Healthcare University of Ukraine, KIA «Forpost», Kyiv, Ukraine Abstract. The aim the study: to analyze clinical cases sensitization dog allergens and tactics management patients in accordance with results component allergodiagnostics. Materials methods research. Analysis these case histories three patients, their clinical, laboratory functional studies. Research results. In all included this study, had complaints...