A5018958936- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cholinesterase and Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Dementia and Cognitive Impairment Research
- Neuroscience and Music Perception
- Neuropeptides and Animal Physiology
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Treatment of Major Depression
- Medicinal Plants and Neuroprotection
- Eating Disorders and Behaviors
- Neuroendocrine regulation and behavior
- Neurological Disease Mechanisms and Treatments
- Mental Health Research Topics
- Ginkgo biloba and Cashew Applications
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
University of Cambridge
2013-2022
Heptares Therapeutics (United Kingdom)
2017-2022
Monash University
2011-2021
Lundbeck (Denmark)
2021
Cambridge Cognition (United Kingdom)
2014-2018
Monash Alfred Psychiatry Research centre
2006-2017
inVentiv Health Clinical
2016
Invent (Germany)
2016
GlaxoSmithKline (United Kingdom)
2007-2015
Swinburne University of Technology
1998-2015
Successful control of affect partly depends on the capacity to modulate negative emotional responses through use cognitive strategies (i.e., reappraisal). Recent studies suggest involvement frontal cortical regions in modulation amygdala reactivity and mediation effective emotion regulation. However, within-subject inter-regional connectivity between prefrontal cortex context regulation is unknown. Here, using psychophysiological interaction analyses functional magnetic resonance imaging...
Effortful cognitive performance is theoretically expected to depend on the formation of a global neuronal workspace. We tested specific predictions workspace theory, using graph theoretical measures network topology and physical distance synchronization, in magnetoencephalographic data recorded from healthy adult volunteers (N = 13) during working memory task at several levels difficulty. found that greater effort caused emergence more globally efficient, less clustered, modular...
Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology psychotic disorders, although differential roles played by dorsal and ventral systems mediating risk for psychosis have contentious.To use resting-state functional magnetic resonance imaging characterize disease-related, risk-related, symptom-related changes patients with first-episode their unaffected first-degree relatives.This case-control cross-sectional study was conducted at a specialist...
Abstract The neuropeptide oxytocin (OXT) plays an important role in complex socio-affective behaviours such as affiliation, attachment, stress and anxiety. Previous studies have focused on the amygdala target of OXT's effects. However, effects OXT connectivity with cortical regions medial frontal cortex, mediator social cognition emotion regulation, remain unexplored. In a randomized, double-blind, cross-over design, 15 volunteers received intranasal or placebo prior to resting-state...
Generalized social anxiety disorder (GSAD) is associated with heightened limbic and prefrontal activation to negative cues conveying threat (e.g. fearful faces), but less known about brain response non-threatening stimuli. The neuropeptide oxytocin (Oxt) has been shown attenuate (and normalize) fear-related reactivity emotionally cues. Here, we examined the effects of intranasal Oxt on cortical sad faces in patients GSAD matched controls (Con). In a double-blind placebo-controlled...
Although obesity is associated with structural changes in brain grey matter, findings have been inconsistent and the precise nature of these unclear. Inconsistencies may partly be due to use different volumetric morphometry methods, inclusion participants comorbidities that exert independent effects on structure. The latter concern particularly critical when sample sizes are modest. purpose current study was examine relationship between cortical matter body mass index (BMI), healthy...
Background Patients with major depressive disorder (MDD) show deficits in processing of facial emotions that persist beyond recovery and cessation treatment. Abnormalities neural areas supporting attentional control emotion remitted depressed (rMDD) patients suggests there may be enduring, trait-like abnormalities key circuits at the interface cognition emotion, but this issue has not been studied systematically. Method Nineteen euthymic, medication-free rMDD (mean age 33.6 years; mean...
Introduction: Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy safety of GSK239512, highly potent, brain penetrant receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheimer's disease (AD). Methods: In this 16-week, double-blind, randomized, parallel group study, 196 currently untreated mild-tomoderate AD (Mini Mental State Examination [MMSE] 16-24)...
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease schizophrenia. While the contribution modulating cognition is well established humans, effects interactions possible synergistic between have not been characterized humans. The current study examined selective simultaneous receptor antagonism on range cognitive processes. was double-blind, placebo-controlled, repeated measures design which 12 healthy, young...
L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. has been historically reported as relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that increases brain serotonin, dopamine, GABA levels and micromolar affinities for AMPA, Kainate NMDA receptors. In addition shown to exert neuroprotective effects animal models possibly through antagonistic group 1 metabotrophic glutamate Behavioural animals...
L-Theanine (delta-glutamylethylamide) is one of the predominant amino acids ordinarily found in green tea, and historically has been used as a relaxing agent. The current study examined acute effects L-theanine comparison with standard benzodiazepine anxiolytic, alprazolam placebo on behavioural measures anxiety healthy human subjects using model anticipatory (AA). Sixteen volunteers received (1 mg), (200 mg) or double-blind placebo-controlled repeated design. were assessed under relaxed...