A5102728321- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Diabetes Management and Research
- Diabetic Foot Ulcer Assessment and Management
- Diabetes Treatment and Management
- Frailty in Older Adults
- Diabetes and associated disorders
- Cardiovascular Health and Disease Prevention
- Retinal Diseases and Treatments
- Pain Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Retinopathy of Prematurity Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin D Research Studies
- Retinal Imaging and Analysis
- Neurological and metabolic disorders
- Genetic Syndromes and Imprinting
- Pancreatic function and diabetes
- Transplantation: Methods and Outcomes
- Diabetes Management and Education
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Function and Risk Factors
- S100 Proteins and Annexins
- Health and Lifestyle Studies
- Nutrition and Health in Aging
King's College London
2017-2025
Kings Health Partners
2022-2023
British Heart Foundation
2023
Guy's and St Thomas' NHS Foundation Trust
2017-2022
Harvard University
2022
Brigham and Women's Hospital
2022
Guy's Hospital
2020
University Hospital of Heraklion
2015-2019
King's College Hospital
2019
University of Crete
2018-2019
Microvascular complications in the heart and kidney are strongly associated with an overall rise inflammation. Annexin A1 (ANXA1) is endogenous anti-inflammatory molecule that limits resolves In this study, we have used a bedside to bench approach investigate: (1) ANXA1 levels individuals type 1 diabetes; (2) role of nephropathy cardiomyopathy experimental (3) whether treatment human recombinant attenuates murine model diabetes. was measured plasma from diabetes or without healthy donors....
Summary The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk dementia. Identifying factors that may contribute to the progress MCI dementia critical. objective this study was examine association sleep performance in patients. A subsample 271 participants diagnosis probable Alzheimer's disease (AD; N = 50) or (MCI; 121) 100 persons who were not cognitively impaired (NI) recruited from large population‐based cohort island Crete,...
Soluble Klotho (sKlotho) is a circulating hormone with cardiovascular-renal protective effects. Whether sKlotho predicts estimated glomerular filtration rate (eGFR) decline in patients type 2 diabetes mellitus (T2DM) relatively preserved renal function unknown. Single-center observational follow-up study of 101 T2DM and eGFR >45 mL/min [91% on renin angiotensin system (RAS) blockade] followed for median 9 years (range, to 13 years). Primary outcome was >50% eGFR. sKlotho, serum phosphorus,...
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in regulatory T-cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, prevents diabetes, shows greater potency when multiple are used. To translate this strategy into the clinical setting, we administered mixture six HLA-DRB1*0401–selective, intradermally patients recent-onset type possessing genotype randomized...
Our aim was to explore the burden of dementia in Cretan Aging Cohort, comprised 3140 persons aged ≥60 years (56.8% women, 5.8 ± 3.3 formal education, 86.2% living rural areas) who attended selected primary health-care facilities on island Crete, Greece. In first study phase, a diagnosis had been reached 4.0% participants. However, when 505 participants underwent thorough neuropsychiatric evaluation second phase this (344 with Mini-Mental State Examination [MMSE] <24 and 161 MMSE ≥24),...
Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism vascular homeostasis through protective effects on the endothelium antioxidant actions. The role soluble patients unknown.In a cross-sectional single-centre study we evaluated levels serum 33 participants history (receiving renin-angiotensin system [RAS] inhibitors) 45 without (not...
Diabetic Foot Ulcers (DFUs) are a common and feared complication of type 1 2 diabetes. People with DFUs often present significant clinical complexity due to multimorbidity, frailty, polypharmacy, disabling conditions. Frailty, defined using the accumulation health deficits model, has shown predict worsening status, hospitalizations, death in older persons. There no studies, date, that have examined prevalence effect frailty on outcomes. The aim our study was explore impact healing...
People with gastroparesis who develop treatment-resistant (refractory) disease pose a difficult challenge, especially in the setting of end-stage renal (ESRD) or post pancreas transplant. Aprepitant (a neurokinin-receptor antagonist) is licensed for short-term treatment chemotherapy-induced nausea. There lack information on its long-term efficacy and safety people diabetic gastroparesis.Case 1 was 73-year-old man Type 2 diabetes 25 years' duration ESRD requiring dialysis. He referred to our...
There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus less-intensive 12-monthly control LSM (C-LSM) intervention on primary composite endpoint predictors cardio-metabolic disease (new onset T2DM, hypertension, impaired glucose tolerance (IGT), fasting glycaemia (IFG) and markers cardio-renal disease) participants aged 5–40 years with risk factors for...
The objective of this study was to evaluate whether aortic pulse wave velocity (Ao-PWV) predicts estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus.This prospective single-center cohort investigated 211 mellitus eGFR ≥45 mL/min a baseline mean age 60.1 years (range, 30-82 years). mean±SD 85±26.1 mL/min. We divided the into groups above (n=117, "older") and below (n=94, "younger") Ao-PWV predicted progression kidney disease differentially older...
Background: Klotho is a circulating anti-ageing hormone that predicts progression of cardiovascular and renal disease. The role in diabetic retinopathy unknown. Methods: We performed single-centre observational study 81 people (males 62%) with type 2 diabetes followed for median 44 months. Circulating levels other markers, were measured from stored samples. primary outcome was defined as new onset or step change grading. Results: During follow-up, 46 (57%) reached the outcome. People had...
Aortic pulse wave velocity (Ao-PWV) predicts cardiovascular and kidney disease in type 2 diabetes (T2D). Klotho is a circulating antiaging hormone (sKlotho) with putative cardiorenal protective effects. The relationship between sKlotho Ao-PWV diabetic (DKD) unknown.In cross-sectional cohort study, the correlation of measured by validated immunoassay, applanation tonometry, was investigated 172 participants T2D early stage DKD (all had estimated glomerular filtration rate [eGFR] >45 ml/min)...
Abstract Aims To assess the prevalence of risk factors for obstructive sleep apnoea in people with diabetic foot ulcers and to determine whether this predicts ulcer healing. Methods We studied 94 consecutive (69% men) (Type 2 diabetes, n =66, Type 1 =28) attending a university hospital unit. All participants were screened using STOP ‐ BANG questionnaire, score ≥4 identifying high apnoea. The primary outcome was poor healing, defined as recurrence (diabetic which healed re‐ulcerated same...
Active vitamin D deficiency is associated with increased aortic-pulse wave velocity (Ao-PWV) in people type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active treatment on Ao-PWV T2DM CKD.A 48-week duration single-centre double-blind parallel-group trial examined impact oral 1,25 dihydroxyvitamin (calcitriol 0.25 mcg OD) as compared to placebo a primary endpoint Ao-PWV. People stable stage 3 CKD intact parathyroid...
OBJECTIVE The aim of the study was to identify demographic and clinical features in an urban cohort people with type 1 diabetes who developed a ≥50% decline estimated glomerular filtration rate (eGFR). RESEARCH DESIGN AND METHODS We evaluated 5,261 (51% female, 13.4% African Caribbean) baseline eGFR &gt;45 mL/min/1.73 m2 between 2004 2018. primary end point from final &lt;30 m2. calculated using Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS Of cohort, 263 (5%)...
Active vitamin-D deficiency is a potential modifiable risk factor for increased ventricular mass. We explored the effects of active (calcitriol) treatment on left mass in patients with type-2 diabetes (T2D) and chronic kidney disease (CKD).We performed 48-week duration single center randomized double-blind parallel group trial examining impact calcitriol, 0.5 mcg once daily, as compared to placebo primary endpoint change from baseline index (LVMI) measured by magnetic resonance imaging ....
OBJECTIVE There is limited information on the effect of ethnicity development referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. This study describes risk factors for STDR a diverse cohort diabetes attending regional eye screening service. RESEARCH DESIGN AND METHODS Clinical and digital retinal imaging data from 1,876 (50% women, 72.1% Caucasian, 17.3% African Caribbean, 2.9% Asian, 7.6% other) no at baseline, surveillance were reviewed. Referable was...
Background: Coronavirus Disease-19 (COVID-19) is implicated in endotheliitis which adversely affects cardiovascular events. The impact of vaccination with COVID-19 on the clinical outcome patients documented. Objective: To evaluate severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2) infection-related endothelial impairment. Methods: We enrolled 45 hospitalized for (either vaccinated or not against SARS-CoV-2). Clinical and laboratory data were collected, brachial artery...