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Zheyuan Guo

ORCID: 0000-0003-0944-7813
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About
Contact & Profiles
A5051410298
Research Areas
  • RNA and protein synthesis mechanisms
  • CRISPR and Genetic Engineering
  • Fungal and yeast genetics research
  • Genomics and Chromatin Dynamics

L'Oreal (United States)
 2023

Institute of Genomics and Integrative Biology
 2023

Harvard University
 2023

Pondicherry University
 2023

Johns Hopkins University
 2014

 Total Synthesis of a Functional Designer Eukaryotic Chromosome
OPENALEX - Publications 
Narayana Annaluru Helöise Müller Leslie A. Mitchell Sivaprakash Ramalingam Giovanni Stracquadanio and 75 more Sarah M. Richardson Jessica S. Dymond Zheng Kuang Lisa Z. Scheifele Eric M. Cooper Yizhi Cai Karen Zeller Neta Agmon Jeffrey S. Han Michalis Hadjithomas Jennifer Tullman Katrina Caravelli Kimberly M. Cirelli Zheyuan Guo Viktoriya London Apurva Yeluru Sindurathy Murugan Karthikeyan Kandavelou Nicolas Agier Gilles Fischer Kun Yang James A. Martin Murat Bilgel Pavlo Bohutskyi Kristin M. Boulier Brian J. Capaldo Joy W. Chang Kristie Charoen Woo Jin Choi Peter Deng James E. DiCarlo J. Y. H. Doong Jessilyn Dunn Jason I. Feinberg Christopher Fernandez Charlotte E. Floria David Gladowski Pasha Hadidi Isabel E. Ishizuka Javaneh Jabbari Calvin Y. L. Lau Pablo A. Lee Sean Li Denise Lin Matthias E. Linder Jonathan P. Ling Jaime Liu Jonathan Liu Mariya London Henry Ma Jessica Mao Jessica E. McDade Alexandra McMillan Aaron M. Moore Won Chan Oh Yu Ouyang Ruchi Patel Marina Paul Laura C. Paulsen Judy Qiu Alex Rhee Matthew G. Rubashkin Ina Y. Soh Nathaniel E. Sotuyo Venkatesh Srinivas Allison Suarez Andy O.-T. Wong Remus Wong Wei Xie Yijie Xu Allen T. Yu Romain Koszul Joel S. Bader Jef D. Boeke Srinivasan Chandrasegaran

Designer Chromosome One of the ultimate aims synthetic biology is to build designer organisms from ground up. Rapid advances in DNA synthesis has allowed assembly complete bacterial genomes. Eukaryotic organisms, with their generally much larger and more complex genomes, present an additional challenge biologists. Annaluru et al. (p. 55 , published online 27 March) designed a eukaryotic chromosome based on yeast III. The chromosome, shorn destabilizing transfer RNA genes transposons, ∼14%...

10.1126/science.1249252 article EN Science 2014-03-28
 Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
OPENALEX - Publications 
Laura H. McCulloch Vijayan Sambasivam Amanda L. Hughes Narayana Annaluru Sivaprakash Ramalingam and 48 more Viola Fanfani Evgenii Lobzaev Leslie A. Mitchell Jitong Cai Hua Jiang John LaCava Martin S. Taylor William R. Bishai Giovanni Stracquadanio Lars M. Steinmetz Joel S. Bader Weimin Zhang Jef D. Boeke Srinivasan Chandrasegaran Breeana G. Anderson Abena Apaw Pavlo Bohutskyi Erin Buchanan Daniel T. Chang M. Chen Eric M. Cooper Amanda Deliere Kallie Drakos Justin Dubin Christopher Fernandez Zheyuan Guo Thomas F. Harrelson Dongwon Lee Jessica E. McDade Scott Melamed Héloise Müller Adithya Murali José U. Niño Rivera Mira C. Patel Mary Rodley Jenna Schwarz Nirav Shelat Josh S. Sims Barrett Steinberg James J. Steinhardt Rishi Trivedi Christopher Von Dollen Tianyi Wang Remus Wong Yijie Xu Noah Young Karen Zeller Allen Zhang

We describe the complete synthesis, assembly, debugging, and characterization of a synthetic 404,963 bp chromosome,

10.1016/j.xgen.2023.100419 article EN cc-by-nc-nd Cell Genomics 2023-11-01
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